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Book

Adenoviruses

Norina Usman  1 , Manuel Suarez  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Adenoviruses

Norina Usman et al.
Free Books & Documents

Excerpt

The adenoviruses are DNA viruses common in animals and humans, frequently occurring in adults and children. There are more than 100 serologically different adenovirus types, with 49 types that infect humans. Adenoviridae is separated into 2 genera: the avian adenoviruses (aviadenoviruses) and the mammalian adenoviruses (mastadenovirus). Adenovirus is ubiquitous in animals, and in human populations, they may last long periods outside of a host, endemic throughout the year.

Based on various serotypes, adenovirus is known as the etiologic mediator of multiple syndromes. It is spread via aerosolized droplets, direct inoculation to the conjunctiva, exposure to infected tissue, blood, and fecal-oral route. The virus infects multiple organ systems, though most infections are asymptomatic. Adenovirus is recognized to be oncogenic in rodents, but it has not yet been observed in humans. Adenovirus infections are self-limited in immunocompetent individuals, requiring only supportive measures. However, in immunocompromised individuals, the spectrum of disease is much more extensive, with outcomes potentially being fatal.

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Conflict of interest statement

Disclosure: Norina Usman declares no relevant financial relationships with ineligible companies.

Disclosure: Manuel Suarez declares no relevant financial relationships with ineligible companies.

References

    1. Lukashev AN, Ivanova OE, Eremeeva TP, Iggo RD. Evidence of frequent recombination among human adenoviruses. J Gen Virol. 2008 Feb;89(Pt 2):380-388. - PubMed
    1. Hartman ZC, Kiang A, Everett RS, Serra D, Yang XY, Clay TM, Amalfitano A. Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. J Virol. 2007 Feb;81(4):1796-812. - PMC - PubMed
    1. ROWE WP, HUEBNER RJ, GILMORE LK, PARROTT RH, WARD TG. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med. 1953 Dec;84(3):570-3. - PubMed
    1. Singh-Naz N, Brown M, Ganeshananthan M. Nosocomial adenovirus infection: molecular epidemiology of an outbreak. Pediatr Infect Dis J. 1993 Nov;12(11):922-5. - PubMed
    1. Chang SY, Lee CN, Lin PH, Huang HH, Chang LY, Ko W, Chang SF, Lee PI, Huang LM, Kao CL. A community-derived outbreak of adenovirus type 3 in children in Taiwan between 2004 and 2005. J Med Virol. 2008 Jan;80(1):102-12. - PubMed

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