Drusen Bodies
- PMID: 32644513
- Bookshelf ID: NBK559087
Drusen Bodies
Excerpt
Drusen bodies are extracellular deposits of lipids, proteins, and cellular debris which are found within the layers of the retina and appear as small, yellow deposits on dilated eye exams. Specifically, drusen reside between the basal lamina of the retinal pigment epithelium (RPE) and the inner layer of the Bruch membrane (BM). These sub-RPE deposits are seen with the progression of normal aging; however, depending on the size, number, location, and type of drusen involved, they can be associated with increased risk of developing age-related macular degeneration (AMD).
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- Bergen AA, Arya S, Koster C, Pilgrim MG, Wiatrek-Moumoulidis D, van der Spek PJ, Hauck SM, Boon CJF, Emri E, Stewart AJ, Lengyel I. On the origin of proteins in human drusen: The meet, greet and stick hypothesis. Prog Retin Eye Res. 2019 May;70:55-84. - PubMed
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- Khan KN, Mahroo OA, Khan RS, Mohamed MD, McKibbin M, Bird A, Michaelides M, Tufail A, Moore AT. Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes. Prog Retin Eye Res. 2016 Jul;53:70-106. - PubMed
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