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Book

Agranulocytosis

Yub Raj Sedhai  1 , Anish Lamichhane  2 , Vikas Gupta  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Agranulocytosis

Yub Raj Sedhai et al.
Free Books & Documents

Excerpt

Neutrophils are the most abundant white blood cell in blood and play a critical role in providing innate immunity against various offending agents. Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving severe and dangerous neutropenia. Agranulocytosis is a condition in which the absolute neutrophil count (ANC) is less than 100 neutrophils per microlitre of blood. People with this condition are at a very high risk of severe infection. Broadly, it can be due to hereditary disease due to genetic mutation or acquired disease. Agranulocytosis can have various presentations, including fever, chills, sore throat, etc. It can be a life-threatening condition that requires prompt diagnosis and treatment.

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Conflict of interest statement

Disclosure: Yub Raj Sedhai declares no relevant financial relationships with ineligible companies.

Disclosure: Anish Lamichhane declares no relevant financial relationships with ineligible companies.

Disclosure: Vikas Gupta declares no relevant financial relationships with ineligible companies.

References

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    1. Wiciński M, Węclewicz MM. Clozapine-induced agranulocytosis/granulocytopenia: mechanisms and monitoring. Curr Opin Hematol. 2018 Jan;25(1):22-28. - PubMed
    1. Kirkwood CF, Smith LL, Rustagi PK, Schentag JJ. Neutropenia associated with beta-lactam antibiotics. Clin Pharm. 1983 Nov-Dec;2(6):569-78. - PubMed

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