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Comment
. 2020 Jul 8;28(1):9-11.
doi: 10.1016/j.chom.2020.06.015.

Listening In: Plasmacytoid DC, Monocyte-Derived DC, and Neutrophil Crosstalk in Antifungal Defense

Xin Liu  1 , Sunny Shin  2
Affiliations
Comment

Listening In: Plasmacytoid DC, Monocyte-Derived DC, and Neutrophil Crosstalk in Antifungal Defense

Xin Liu et al. Cell Host Microbe. .

Abstract

Plasmacytoid DCs (pDCs) are typically thought to be key in antiviral defense. In this issue of Cell Host & Microbe, Guo, Kasahara et al. (2020) reveal a critical role for pDCs in antifungal immunity. Aspergillus-infected monocyte-derived DCs and neutrophils recruit pDCs, which promote neutrophil fungicidal activity.

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Figures

Figure 1.
Figure 1.. Mo-DCs and NΦs Mediate CXCR3-Dependent Recruitment of pDCs, which Enhance NΦ Fungicidal Activity
During A. fumigatus infection, pDCs egress from the bone marrow in a CCR2-dependent manner and are recruited into the lung in a CXCR3-dependent manner. The CXCR3 ligands CXCL9 and CXCL10 are predominantly produced by Mo-DCs and NΦs upon Dectin-1 recognition of conidia β-glucan and type I/III IFN (IFN-α/β and IFN-λ) signaling; whether Mo-DC- and NΦ-intrinsic Dectin-1 and IFNR signaling regulates chemokine production remains unclear. Once within the lung, pDCs enhance NΦ-specific ROS production, resulting in conidial killing; the mechanism underlying how pDCs regulate ROS production in NΦs remains to be determined. Abbreviations are as follows: pDCs, plasmacytoid dendritic cells; Mo-DCs, monocyte-derived dendritic cells; NΦs, neutrophils; IFNs, interferons; IFNRs, interferon receptors; ROS, reactive oxygen species.
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References

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