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. 2020 Jul 7;25(13):3099.
doi: 10.3390/molecules25133099.

Quasi-Isostructural Co(II) and Ni(II) Complexes with Mefenamato Ligand: Synthesis, Characterization, and Biological Activity

Michał Gacki  1 , Karolina Kafarska  1 , Anna Pietrzak  1 , Izabela Korona-Głowniak  2 , Wojciech M Wolf  1
Affiliations

Quasi-Isostructural Co(II) and Ni(II) Complexes with Mefenamato Ligand: Synthesis, Characterization, and Biological Activity

Michał Gacki et al. Molecules. .

Abstract

Three metal complexes of mefenamato ligand 1 were synthesized: [Co2(mef)4(EtOH)2(H2O)4]: 2; [Co(mef)2(MeOH)4]∙2MeOH: 3; and [Ni(mef)2(MeOH)4]∙2MeOH: 4. Their compositions and properties were investigated by elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Crystal structures were determined by the single crystal X-ray diffraction technique. Additionally, their antioxidant and antimicrobial activity were established, thus proving good/moderate bioactivity against Gram-positive bacteria and yeasts. In the crystal structure of 2, an apical water molecule is shared between two adjacent cobalt(II) ions, resulting in the formation of a polymeric chain extending along the [100] direction. Meanwhile, structures 3 and 4 have strong intermolecular hydrogen bonds with diverse topologies that yield unique quasi-isostructural arrangements. The packing topology is reflected by the Hirshfeld surface analysis of intermolecular contacts.

Keywords: antioxidant activity; mefenamic acid; non-steroidal anti-inflammatory drug-complex; quasi-isotructural; thermal analysis.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Scheme 1
Scheme 1
Structural schemes of 1–4.
Figure 1
Figure 1
The crystal structure of 2. Hydrogen atoms are omitted for clarity. Displacement ellipsoids are drawn at the 50% probability level. Only the asymmetric unit is labeled, and the major component of disordered atoms are display for clarity.
Figure 2
Figure 2
Molecular structures of 3(a) and 4(b). Hydrogen atoms are omitted for clarity. Displacement ellipsoids are drawn at the 50% probability level. Only asymmetric units are labeled.
Figure 3
Figure 3
Superposition of structures 3 (red) and 4 (green). Hydrogen atoms and methanol O5 molecules in the outer coordination sphere are omitted for clarity.
Figure 4
Figure 4
(a) Hirshfeld surfaces generated for the mer unit of 2 and the single molecules of 3 and 4. (b) Fingerprint plots generated for respective moieties. Labels indicate regions of specific interatomic interactions. (c) The percentage contributions to the Hirshfeld surface areas for intermolecular contacts.
Figure 5
Figure 5
Thermoanalytical curves for 2 (a), 3 (b), and 4 (c). TG is plotted in green, DTG is in blue, while DTA is in red.
Figure 6
Figure 6
The radical scavenging activities for all complexes. Mefenamic acid (pale purple) is given as a reference.
See this image and copyright information in PMC

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