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. 2020 Jul 9;20(1):487.
doi: 10.1186/s12879-020-05216-y.

Influence of blood group, Glucose-6-phosphate dehydrogenase and Haemoglobin genotype on Falciparum malaria in children in Vihiga highland of Western Kenya

Jafaralli Sande Ahmed  1   2 , Bernard Guyah  1 , David Sang'  1 , Mark Kilongosi Webale  3   4 , Nathan Shaviya Mufyongo  4 , Elly Munde  3 , Collins Ouma  5
Affiliations

Influence of blood group, Glucose-6-phosphate dehydrogenase and Haemoglobin genotype on Falciparum malaria in children in Vihiga highland of Western Kenya

Jafaralli Sande Ahmed et al. BMC Infect Dis. .

Abstract

Background: Genetic diversity of ABO blood, glucose-6-phosphate dehydrogenase (G6PD) deficiency and haemoglobin type and their ability to protect against malaria vary geographically, ethnically and racially. No study has been carried out in populations resident in malaria regions in western Kenya.

Method: A total of 574 malaria cases (severe malaria anaemia, SMA = 137 and non-SMA = 437) seeking treatment at Vihiga County and Referral Hospital in western Kenya, were enrolled and screened for ABO blood group, G6PD deficiency and haemoglobin genotyped in a hospital-based cross-sectional study.

Result: When compared to blood group O, blood groups A, AB and B were not associated with SMA (P = 0.380, P = 0.183 and P = 0.464, respectively). Further regression analysis revealed that the carriage of the intermediate status of G6PD was associated with risk to SMA (OR = 1.52, 95%CI = 1.029-2.266, P = 0.035). There was, however, no association between AS and SS with severe malaria anaemia. Co-occurrence of both haemoglobin type and G6PD i.e. the AA/intermediate was associated with risk to SMA (OR = 1.536, 95%CI = 1.007-2.343, P = 0.046) while the carriage of the AS/normal G6PD was associated with protection against SMA (OR = 0.337, 95%CI = 0.156-0.915, P = 0.031).

Conclusion: Results demonstrate that blood group genotypes do not have influence on malaria disease outcome in this region. Children in Vihiga with blood group O have some protection against malaria. However, the intermediate status of G6PD is associated with risk of SMA. Further, co-inheritance of sickle cell and G6PD status are important predictors of malaria disease outcome. This implies combinatorial gene function in influencing disease outcome.

Keywords: Children; Genetic variants; Malaria; Western Kenya.

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Conflict of interest statement

Nothing to report.

References

    1. WHO . World Malaria Day 2018 “Ready to beat malaria”. 2018.
    1. Al-Harthi SA. Malaria drug resistant: current situation with reference to Saudi Arabia (review) J Egypt Soc Parasitol. 2011;41(3):553–564. - PubMed
    1. Driss A, Hibbert JM, Wilson NO, Iqbal SA, Adamkiewicz TV, Stiles JK. Genetic polymorphisms linked to susceptibility to malaria. Malar J. 2011;10:271. doi: 10.1186/1475-2875-10-271. - DOI - PMC - PubMed
    1. Kaul DK, Roth EFJ, Nagel RL, Howard RJ, Handunnetti SM. Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions. Blood. 1991;78(3):812–819. doi: 10.1182/blood.V78.3.812.812. - DOI - PubMed
    1. Carlson J, Wahlgren M. Plasmodium falciparum erythrocyte rosetting is mediated by promiscuous lectin-like interactions. J Exp Med. 1992;176(5):1311–1317. doi: 10.1084/jem.176.5.1311. - DOI - PMC - PubMed

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