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. 2021 Jan 30;101(2):497-504.
doi: 10.1002/jsfa.10658. Epub 2020 Aug 4.

Neuroprotective effects of mango cv. 'Ataulfo' peel and pulp against oxidative stress in streptozotocin-induced diabetic rats

Rosario Cázares-Camacho  1 , J Abraham Domínguez-Avila  2 , Humberto Astiazarán-García  3 , Marcelino Montiel-Herrera  4 , Gustavo A González-Aguilar  1
Affiliations

Neuroprotective effects of mango cv. 'Ataulfo' peel and pulp against oxidative stress in streptozotocin-induced diabetic rats

Rosario Cázares-Camacho et al. J Sci Food Agric. .

Abstract

Background: Oxidative stress has been implicated in the pathogenesis and progression of diabetes mellitus. Both can damage the brain. Mango and its by-products are sources of bioactive compounds with antioxidant properties. We hypothesized that mango cv. 'Ataulfo' peel and pulp mitigate oxidative stress in the brain of streptozotocin-induced diabetic rats.

Results: Twenty-four male Wistar rats were divided into four groups: control, untreated diabetic (UD), diabetic treated with a mango-supplemented diet (MTD), and diabetic pretreated with a mango-supplemented diet (MPD). The rats were fed the different diets for 4 weeks after diabetes induction (MTD), or 2 weeks before and 4 weeks after induction (MPD). After the intervention, serum and brain (cerebellum and cortex) were collected to evaluate gene expression, enzyme activity, and redox biomarkers. Superoxide dismutase 2 (SOD2) expression increased in the cortex of the MTD group, whereas glutathione-S-transferase p1 (GSTp1) expression was higher in the cortex of the MTD group, and cortex and cerebellum of the MPD group. SOD1 activity was higher in the cerebellum and cortex of all diabetic groups, whereas GST activity increased in the cerebellum and cortex of the MPD group. Lipid peroxidation increased in the cerebellum and cortex of the UD group; however, a mango-supplemented diet prevented this increase in both regions, while also mitigating polyphagia and weight loss, and maintaining stable glycemia in diabetic rats.

Conclusion: We propose that mango exerts potent neuroprotective properties against diabetes-induced oxidative stress. It can be an alternative to prevent and treat biochemical alterations caused by diabetes. © 2020 Society of Chemical Industry.

Keywords: byproducts; diabetes; neuroprotection; oxidative stress.

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References

REFERENCES

    1. Erukainure OL, Ijomone OM, Oyebode OA, Chukwuma CI, Aschner M and Islam MS, Hyperglycemia-induced oxidative brain injury: therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetes rats. Food Chem Toxicol 127:206-217 (2019).
    1. Osorio-Paz I, Ramírez-Pérez G, Hernández-Ramírez JE, Uribe-Carvajal S and Salceda R, Mitochondrial activity in different regions of the brain at the onset of streptozotocin-induced diabetes in rats. Mol Biol Rep 45:871-879 (2018).
    1. Grunberger G, Should side effects influence the selection of Antidiabetic therapies in type 2 diabetes? Curr Diab Rep 17:21 (2017).
    1. Vinayagam R, Xiao J and Xu B, An insight into anti-diabetic properties of dietary phytochemicals. Phytochem Rev 16:535-553 (2017).
    1. Yin X, Chen Y, Lu W, Jin T and Li L, Association of dietary patterns with the newly diagnosed diabetes mellitus and central obesity: a community based cross-sectional study. Nut Diab 10:16 (2020).

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