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Review
. 2020 Sep;105(9):1440-1443.
doi: 10.1113/EP087872. Epub 2020 Aug 3.

Perivascular adipose tissue: An immune cell metropolis

S N Saxton  1 , A M Heagerty  1 , S B Withers  1   2   3
Affiliations
Free article
Review

Perivascular adipose tissue: An immune cell metropolis

S N Saxton et al. Exp Physiol. 2020 Sep.
Free article

Abstract

New findings: What is the topic of this review? The review discusses how eosinophils can contribute to the function of perivascular adipose tissue and explores the mechanisms involved. What advances does it highlight? Understanding the communication between the cell populations that constitute perivascular adipose tissue function is important for exploring therapeutic options in the treatment of obesity-related cardiovascular complications. This article highlights that eosinophils are able to contribute directly to healthy perivascular adipose tissue function. These immune cells contribute to adrenergic signalling and nitric oxide- and adiponectin-dependent mechanisms in perivascular adipose tissue.

Abstract: Perivascular adipose tissue is a heterogeneous tissue that surrounds most blood vessels in the body. This review focuses on the contribution of eosinophils located within the adipose tissue to vascular contractility. A high-fat diet reduces the number of these immune cells within perivascular adipose tissue, and this loss is linked to an increase in vascular contractility and hypertension. We explored the mechanisms by which eosinophils contribute to this function using genetically modified mice, ex vivo assessment of contractility and pharmacological tools. We found that eosinophils contribute to adrenergic signalling and nitric oxide- and adiponectin-dependent mechanisms in perivascular adipose tissue. It is now important to explore whether manipulation of these pathways in obesity can alleviate cardiovascular complications, in order to determine whether eosinophils are a valid target for obesity-related disease.

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References

REFERENCES

    1. Aghamohammadzadeh, R., Greenstein, A. S., Yadav, R., Jeziorska, M., Hama, S., Soltani, F., …Heagerty, A. M. (2013). Effects of bariatric surgery on human small artery function: Evidence for reduction in perivascular adipocyte inflammation, and the restoration of normal anticontractile activity despite persistent obesity. Journal of the American College of Cardiology, 62, 128-135.
    1. Ahima, R. S., & Flier, J. S. (2000). Adipose tissue as an endocrine organ. Trends in Endocrinology and Metabolism, 11, 327-332.
    1. Almabrouk, T. A. M., White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., … Kennedy, S. (2018). High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51.
    1. Amarsaikhan, N., Tsoggerel, A., Hug, C., & Templeton, S. P. (2019). The metabolic cytokine adiponectin inhibits inflammatory lung pathology in invasive aspergillosis. Journal of Immunology, 203, 956-963.
    1. Bulloch, J. M., & Daly, C. J. (2014). Autonomic nerves and perivascular fat: Interactive mechanisms. Pharmacology & Therapeutics, 143, 61-73.

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