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Editorial
. 2020 Oct;91(10):1033-1034.
doi: 10.1136/jnnp-2020-323457. Epub 2020 Jul 10.

Combining clinical and molecular heterogeneity within CASPR2-antibody mediated diseases: towards the underlying disease biology

Sophie Binks  1 , Sarosh R Irani  2
Affiliations
Editorial

Combining clinical and molecular heterogeneity within CASPR2-antibody mediated diseases: towards the underlying disease biology

Sophie Binks et al. J Neurol Neurosurg Psychiatry. 2020 Oct.
No abstract available

Keywords: autoimmune encephalitis; clinical neurology; immunology; neurogenetics; neuroimmunology.

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Conflict of interest statement

Competing interests: SRI is a co-applicant and receives royalties on patent application WO/2010/046716 entitled ‘Neurological Autoimmune Disorders’. The patent has been licensed to Euroimmun AG for the development of assays for LGI1 and other VGKC-complex antibodies. SRI and SB are coinventors on ‘A Diagnostic Strategy to improve specificity of CASPR2 antibody detection.’ Ref. JA94536P.

Comment on

  • Anti-CASPR2 clinical phenotypes correlate with HLA and immunological features.
    Muñiz-Castrillo S, Joubert B, Elsensohn MH, Pinto AL, Saint-Martin M, Vogrig A, Picard G, Rogemond V, Dubois V, Tamouza R, Maucort-Boulch D, Honnorat J. Muñiz-Castrillo S, et al. J Neurol Neurosurg Psychiatry. 2020 Oct;91(10):1076-1084. doi: 10.1136/jnnp-2020-323226. Epub 2020 Jul 10. J Neurol Neurosurg Psychiatry. 2020. PMID: 32651251

References

    1. Irani SR, Alexander S, Waters P, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain 2010;133:2734–48. 10.1093/brain/awq213 - DOI - PMC - PubMed
    1. Irani SR, Pettingill P, Kleopa KA, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol 2012;72:241–55. 10.1002/ana.23577 - DOI - PubMed
    1. Syrbe S, Stettner GM, Bally J, et al. Caspr2 autoimmunity in children expanding to mild encephalopathy with hypertension. Neurology 2020;94:e2290–301. 10.1212/WNL.0000000000009523 - DOI - PubMed
    1. Binks SNM, Klein CJ, Waters P, et al. Lgi1, Caspr2 and related antibodies: a molecular evolution of the phenotypes. J Neurol Neurosurg Psychiatry 2018;89:526–34. 10.1136/jnnp-2017-315720 - DOI - PMC - PubMed
    1. Muñiz-Castrillo S, Joubert B, Elsensohn M-H, et al. Anti-CASPR2 clinical phenotypes correlate with HLA and immunological features. J Neurol Neurosurg Psychiatry 2020;91:1076–84. 10.1136/jnnp-2020-323226 - DOI - PubMed