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. 2020 Jul 11:26:e923375.
doi: 10.12659/MSM.923375.

Clinicopathological Characteristics and Survival Outcomes of Primary Hepatic Neuroendocrine Tumor: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study

Yu-Feng Li  1   2 , Qiu-Qiang Zhang  1   2 , Wei-Lin Wang  1   2   3   4
Affiliations

Clinicopathological Characteristics and Survival Outcomes of Primary Hepatic Neuroendocrine Tumor: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study

Yu-Feng Li et al. Med Sci Monit. .

Abstract

BACKGROUND Primary hepatic neuroendocrine tumor (PHNET) is a rare primary liver tumor that remains poorly understood. Here, we explored the clinicopathological characteristics and survival outcomes of PHNET patients. MATERIAL AND METHODS PHNET patients diagnosed between 1988 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were enrolled in the cohort. Kaplan-Meier analysis was used to determine the survival outcomes. Multivariable Cox regression models were used to identify the risk factors for overall survival (OS) and disease-specific survival (DSS). RESULTS A total of 291 PHNET patients from the SEER database met the inclusion criteria for analysis. The majority of the patients were female (53.6%), white (77.7%), and married (49.5%). The 1-, 3-, and 5-year OS were 57.1%, 39.4%, and 30.2%, and the 1-, 3-, and 5-year DSS rates were 61.3%, 44.3%, and 36.7%, respectively. Multivariate Cox regression models showed that older age, unmarried status, poor differentiated grade, and no tumor-directed surgery were independent risk factors for poor OS and DSS. CONCLUSIONS Older age, unmarried status, poor differentiated grade, and no tumor-directed surgery were associated with poorer prognosis of PHNET. Surgical resection is an effective and reliable treatment method for patients with PHNET.

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Figures

Figure 1
Figure 1
The distribution of age and sex of all PHNET patients.
Figure 2
Figure 2
Kaplan-Meier analysis of overall survival (A) and disease-specific survival (B) in PHNET patients.
Figure 3
Figure 3
Kaplan-Meier analysis of overall survival in PHNET patients according to (A) Sex, (B) Age, (C) Marital status, (D) Histological grade, (E) SEER stage, (F) Tumor-directed surgery.
Figure 4
Figure 4
Kaplan-Meier analysis of disease-specific survival in PHNET patients according to (A) Sex, (B) Age, (C) Marital status, (D) Histological grade, (E) SEER stage, (F) Tumor-directed surgery.
See this image and copyright information in PMC

References

    1. Cives M, Strosberg JR. Gastroenteropancreatic neuroendocrine tumors. Cancer J Clin. 2018;68:471–87. - PubMed
    1. Dasari A, Shen C, Halperin D, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017;3:1335–42. - PMC - PubMed
    1. Frilling A, Åkerström G, Falconi M, et al. Neuroendocrine tumor disease: An evolving landscape. Endocr Relat Cancer. 2012;19:R163–85. - PubMed
    1. Quartey Primary hepatic neuroendocrine tumor: What do we know now? World J Oncol. 2011;2:209–16. - PMC - PubMed
    1. Edmonson HA. Tumors of the liver and intrahepatic bile ducts. Atlas Tumor Pathol. 1958;7:129–31.

MeSH terms

Supplementary concepts