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Case Reports
. 2020 Sep;8(8):2793-2795.
doi: 10.1016/j.jaip.2020.06.046. Epub 2020 Jul 8.

Rapid recovery of a SARS-CoV-2-infected X-linked agammaglobulinemia patient after infusion of COVID-19 convalescent plasma

Affiliations
Case Reports

Rapid recovery of a SARS-CoV-2-infected X-linked agammaglobulinemia patient after infusion of COVID-19 convalescent plasma

Estefanía Mira et al. J Allergy Clin Immunol Pract. 2020 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Upper panel: CT displaying bilateral pulmonary involvement in the form of nodular consolidations and ground-glass opacities primarily in the left lower lobe (red arrow) and small-size left pleural effusion (black arrow). Lower panel: CT of the chest 6 days after COVID-19 convalescent donor plasma transfusion showing almost complete resolution of bilateral lung lesions pattern. CT, Computed tomography.
Figure 2
Figure 2
(A) Flow cytometric double fluorescence analysis of CD8 cells showing coexpression of surface CD3 (upper panel) and intracytoplasmic TNF-α (middle panel) or IFN-γ (lower panel) after cell stimulation. (B) Blood peripheral T lymphocytes and NK-cell counts determined on days 0, 3, and 7 postinfusion of COVID-19 convalescent plasma.

References

    1. Burton D.R. Antibodies, viruses and vaccines. Nat Rev Immunol. 2002;2:706–713. - PubMed
    1. Fill L., Hadney L., Graven K., Persaud R., Hostoffer R. The clinical observation of a CVID patient infected with COVID-19. Ann Allergy Asthma Immunol. 2020;125:112–114. - PMC - PubMed
    1. Quinti I., Lougaris V., Milito C., Cinetto F., Pecoraro A., Mezzaroma I. A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia. J Allergy Clin Immunol. 2020;146:211–213.e4. - PMC - PubMed
    1. Soresina A., Moratto D., Chiarini M., Paolillo C., Baresi G., Foca E. Two X-linked agammaglobulinemia patients develop pneumonia as COVID-19 manifestation but recover. Pediatr Allergy Immunol. 2020;31:565–569. - PMC - PubMed
    1. Zheng M., Gao Y., Wang G., Song G., Liu S., Sun D. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020;17:533–535. - PMC - PubMed

Publication types

Supplementary concepts