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. 2020 Oct;40(10):2439-2444.
doi: 10.1111/liv.14597. Epub 2020 Jul 25.

NAFLD is related to Post-prandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction

Bart J Verwer  1 , Peter G Scheffer  2 , Rick P Vermue  2 , Petra J Pouwels  3 , Michaela Diamant  4 , Maarten E Tushuizen  1
Affiliations

NAFLD is related to Post-prandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction

Bart J Verwer et al. Liver Int. 2020 Oct.

Abstract

NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with post-prandial hypertriglyceridemia, potentially contributing to triglyceride-enrichment of high-density lipoproteins (HDL-TG), and subsequent HDL dysfunction. We assessed liver fat by MR spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow-mediated dilation (FMD), before and following three consecutive meals, in 36 men with type 2 diabetes mellitus (T2DM), with the MetS, and controls. Plasma triglycerides increased significantly following the meals (P < .001). Fasting HDL-TG was highest in T2DM, relative to MetS and controls (P = .002), and increased post-prandially in all groups (P < .001). HDL function was negatively associated with HDL-TG following three meals (r = -.32, P<.05). Liver fat associated with HDL-TG after three meals (r = .65, P < .001). HDL-TG was independently associated with FMD following three consecutive meals (r = -.477, P = .003). We conclude liver fat is associated with post-prandial HDL-TG enrichment which was closely related with endothelial and HDL dysfunction.

Keywords: HDL; NAFLD - post-prandial dyslipidemia - type 2 diabetes; metabolic syndrome.

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Conflict of interest statement

All authors have no competing financial and non‐financial interests.

Figures

Figure 1
Figure 1
The 16‐h course of plasma glucose (A), triglyceride (B), apoB (C), HDL cholesterol (D), HDL‐TG concentrations (E), and flow‐mediated dilatation (FMD)(F) after three high‐fat mixed meals in T2DM (open circles), MetS (asterisk) and healthy males (solid circles). Bars (black, healthy males; grey, metabolic syndrome (MetS); white, type 2 diabetes mellitus (T2DM)) in the insets represent respective 16‐h AUC values. The P value given for 16‐h AUC difference (ANOVA). Data are mean ± SE. Scatter plots representing the relationship between liver fat content (G) and FMD (H), and HDL‐TG enrichment following three high‐fat mixed meals in the whole study population (groups are indicated by open circles (T2DM), asterisk (MetS) and solid circles (healthy males)). Pearson correlation coefficients are shown
See this image and copyright information in PMC

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