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. 2021 Jan;38(1):17-27.
doi: 10.1002/da.23072. Epub 2020 Jul 11.

Association between anhedonia and suicidal events in patients with mood disorders: A 3-year prospective study

Déborah Ducasse  1   2   3 , Jonathan Dubois  2 , Isabelle Jaussent  2 , Jean-Michel Azorin  3   4 , Bruno Etain  3   5 , Sébastien Gard  3   6 , Chantal Henry  3   5 , Thierry Bougerol  3   7 , Jean-Pierre Kahn  3   8 , Valérie Aubin  3   9 , Frank Bellivier  3   10 , Raoul Belzeaux  3   4 , Caroline Dubertret  3   11   12 , Julien Dubreucq  3   7 , Pierre-Michel Llorca  13 , Josephine Loftus  3   9 , Christine Passerieux  3   14 , Mircea Polosan  3   7 , Ludovic Samalin  13 , Marion Leboyer  3   5 , Antoine Yrondi  3   15 , Djamila Bennabi  3   16 , Emmanuel Haffen  3   17 , Julia Maruani  3   18 , Etienne Allauze  3   13 , Vincent Camus  19 , Thierry D'Amato  20 , Olivier Doumy  6 , Jérôme Holtzmann  7 , Christophe Lançon  21 , Fanny Moliere  1 , Rémi Moirand  20 , Raphaëlle Marie Richieri  21 , Mathilde Horn  22 , Laurent Schmitt  15 , Florian Stephan  23 , Jean-Baptiste Genty  13 , Guillaume Vaiva  22 , Michel Walter  23 , Wissam El-Hage  19 , Bruno Aouizerate  6 , Emilie Olié  1   2   3 , Philippe Courtet  1   2   3
Affiliations

Association between anhedonia and suicidal events in patients with mood disorders: A 3-year prospective study

Déborah Ducasse et al. Depress Anxiety. 2021 Jan.

Abstract

Background: As almost all mental disorders are associated with increased suicidal-related behavior, anhedonia might be a trans-diagnostic dimension to target for suicide prevention.

Methods: For this 3-year-long prospective study, 2,839 outpatients with mood disorders were recruited. They were divided in: (a) two groups according to the occurrence or not of suicidal ideation during the follow-up, and (b) two groups according to the occurrence or not of suicide attempts during the follow-up. Anhedonia was assessed using a composite score (the French version of the 14-item Snaith-Hamilton Pleasure Scale and item 13 of the Quick Inventory of Depressive Symptomatology scale) at inclusion and at 6, 12, 24, and 36 months after inclusion.

Results: Patients with mood disorders and anhedonia at least at one follow-up visit had a 1.4-fold higher risk of suicidal ideation (adjusted odds ratio = 1.35; 95% confidence interval [1.07, 1.70]), even after adjustment for confounding factors of suicide risk (i.e., bipolar or unipolar disorder, sex, age, marital status, education level, antidepressant intake, personal history of suicide attempt, at least one childhood trauma, and mean of the maximum depression score during the follow-up). Conversely, association between anhedonia and suicide attempt did not remain significant after adjustment.

Conclusions: The significant association between anhedonia and suicide ideation in patients with mood disorders stresses the need of targeting hedonia in mood disorders, and of research focusing on the position to pleasure in life through eudaimonia.

Keywords: anhedonia; mood disorder; prospective study; suicidal ideation; suicide attempt.

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References

REFERENCES

    1. American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders (DSM-5®) (5th ed.). Washington, DC.
    1. Amrhein, V., Greenland, S., & McShane, B. (2019). Scientists rise up against statistical significance. Nature, 567(7748), 305-307.
    1. Arias-Carrión, Ó., & Pöppel, E. (2007). Dopamine, learning, and reward-seeking behavior. Acta Neurobiologiae Experimentalis, 67, 481-488.
    1. Arsenault, J. T., Rima, S., Stemmann, H., & Vanduffel, W. (2014). Role of the primate ventral tegmental area in reinforcement and motivation. Current Biology, 24, 1347-1353.
    1. Auerbach, R. P., Millner, A. J., Stewart, J. G., & Esposito, E. C. (2015). Identifying differences between depressed adolescent suicide ideators and attempters. Journal of Affective Disorders, 186, 127-133.

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