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Case Reports
. 2021 May:88:102464.
doi: 10.1016/j.bcmd.2020.102464. Epub 2020 Jul 2.

Daratumumab for pure red cell aplasia post ABO incompatible allogeneic hematopoietic stem cell transplant for aplastic anemia

Preethi Jeyaraman  1 , Pronamee Borah  2 , Priyanka Rajput  2 , Nitin Dayal  3 , Sangeeta Pathak  4 , Rahul Naithani  2
Affiliations
Case Reports

Daratumumab for pure red cell aplasia post ABO incompatible allogeneic hematopoietic stem cell transplant for aplastic anemia

Preethi Jeyaraman et al. Blood Cells Mol Dis. 2021 May.

Abstract

Pure red cell aplasia is a known complication after ABO incompatible stem cell transplant. Due to rarity of disease, no established treatment guidelines are available for PRCA. Daratumumab is a monoclonal antibody against CD38 expressed by plasma cells. In this report we present our experience of successfully managing a patient of post-transplant PRCA with daratumumab. Our patient had failed multiple lines of therapy prior to receiving daratumumab. Response was seen after the 3rd weekly dose of daratumumab.

Keywords: ABO incompatibility; Daratumumab; Delayed RBC engraftment; Pure red cell aplasia.

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