Review

. 2020 Sep:35:43-49.

doi: 10.1016/j.prrv.2020.06.010. Epub 2020 Jun 18.

Vaccines for COVID-19: The current state of play

Archana Koirala¹, Ye Jin Joo², Ameneh Khatami³, Clayton Chiu⁴, Philip N Britton⁵

Affiliations

¹ National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia; Department of Infectious Diseases, Nepean Hospital, Penrith, NSW, Australia. Electronic address: Archana.Koirala@health.nsw.gov.au.
² National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia. Electronic address: YeJin.Joo@health.nsw.gov.au.
³ Sydney Medical School, The University of Sydney, NSW, Australia; Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, NSW, Australia. Electronic address: ameneh.khatami@health.nsw.gov.au.
⁴ National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, NSW, Australia. Electronic address: clayton.chiu@health.nsw.gov.au.
⁵ Sydney Medical School, The University of Sydney, NSW, Australia; Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, NSW, Australia. Electronic address: philip.britton@health.nsw.gov.au.

PMID: 32653463
PMCID: PMC7301825
DOI: 10.1016/j.prrv.2020.06.010

Review

Vaccines for COVID-19: The current state of play

Archana Koirala et al. Paediatr Respir Rev. 2020 Sep.

. 2020 Sep:35:43-49.

doi: 10.1016/j.prrv.2020.06.010. Epub 2020 Jun 18.

Authors

Archana Koirala¹, Ye Jin Joo², Ameneh Khatami³, Clayton Chiu⁴, Philip N Britton⁵

Affiliations

¹ National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia; Department of Infectious Diseases, Nepean Hospital, Penrith, NSW, Australia. Electronic address: Archana.Koirala@health.nsw.gov.au.
² National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia. Electronic address: YeJin.Joo@health.nsw.gov.au.
³ Sydney Medical School, The University of Sydney, NSW, Australia; Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, NSW, Australia. Electronic address: ameneh.khatami@health.nsw.gov.au.
⁴ National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, NSW, Australia. Electronic address: clayton.chiu@health.nsw.gov.au.
⁵ Sydney Medical School, The University of Sydney, NSW, Australia; Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, NSW, Australia. Electronic address: philip.britton@health.nsw.gov.au.

PMID: 32653463
PMCID: PMC7301825
DOI: 10.1016/j.prrv.2020.06.010

Abstract

There is a strong consensus globally that a COVID-19 vaccine is likely the most effective approach to sustainably controlling the COVID-19 pandemic. An unprecedented research effort and global coordination has resulted in a rapid development of vaccine candidates and initiation of trials. Here, we review vaccine types, and progress with 10 vaccine candidates against SARS-CoV-2 - the virus that causes COVID-19 - currently undergoing early phase human trials. We also consider the many challenges of developing and deploying a new vaccine on a global scale, and recommend caution with respect to our expectations of the timeline that may be ahead.

Keywords: Covid 19; Human trials; Timeline; Vaccines.

PubMed Disclaimer

Figures

**Fig. 1**
Schematic of the structure of SARS-CoV2. *(Adapted from Lee, C-Y et al, Frontiers in Immunology, 2020)*.

See this image and copyright information in PMC

Cited by

Evaluating the impact of COVID-19: A cohort comparison study of drug use and risky sexual behavior among sexual minority men in the U.S.A.
Starks TJ, Jones SS, Sauermilch D, Benedict M, Adebayo T, Cain D, Simpson KN. Starks TJ, et al. Drug Alcohol Depend. 2020 Nov 1;216:108260. doi: 10.1016/j.drugalcdep.2020.108260. Epub 2020 Aug 28. Drug Alcohol Depend. 2020. PMID: 32890975 Free PMC article.
Impact of Economic Policy Uncertainty and Pandemic Uncertainty on International Tourism: What do We Learn From COVID-19?
Zhao X, Meo MS, Ibrahim TO, Aziz N, Nathaniel SP. Zhao X, et al. Eval Rev. 2023 Apr;47(2):320-349. doi: 10.1177/0193841X221132125. Epub 2022 Oct 18. Eval Rev. 2023. PMID: 36255210 Free PMC article.
Psychometric development of the COVID-19 vaccine misinformation scale and effects on vaccine hesitancy.
Bok S, Martin D, Acosta E, Shum J, Harvie J, Lee M. Bok S, et al. Prev Med Rep. 2023 Feb;31:102087. doi: 10.1016/j.pmedr.2022.102087. Epub 2022 Dec 6. Prev Med Rep. 2023. PMID: 36505271 Free PMC article.
Analysis of Key Factors of a SARS-CoV-2 Vaccination Program: A Mathematical Modeling Approach.
Martínez-Rodríguez D, Gonzalez-Parra G, Villanueva RJ. Martínez-Rodríguez D, et al. Epidemiologia (Basel). 2021 Jun;2(2):140-161. doi: 10.3390/epidemiologia2020012. Epub 2021 Apr 1. Epidemiologia (Basel). 2021. PMID: 35141702 Free PMC article.
A meta-analysis result: Uneven influences of season, geo-spatial scale and latitude on relationship between meteorological factors and the COVID-19 transmission.
Li HL, Yang BY, Wang LJ, Liao K, Sun N, Liu YC, Ma RF, Yang XD. Li HL, et al. Environ Res. 2022 Sep;212(Pt B):113297. doi: 10.1016/j.envres.2022.113297. Epub 2022 Apr 15. Environ Res. 2022. PMID: 35436453 Free PMC article.

See all "Cited by" articles

References

1. Zhu N. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020 - PMC - PubMed
1. Wu F. A new coronavirus associated with human respiratory disease in China. Nature. 2020;579(7798):265–269. - PMC - PubMed
1. Centre for Systems Science and Engineering. COVID-19 Dashboard. 2020 [cited 2020 June 3, 2020]; Available from: https://coronavirus.jhu.edu/map.html.
1. Guan W.-J. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708–1720. - PMC - PubMed
1. Chen N. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Vaccines for COVID-19: The current state of play

Affiliations

Vaccines for COVID-19: The current state of play

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Miscellaneous