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. 2020 Nov:510:60-61.
doi: 10.1016/j.cca.2020.07.012. Epub 2020 Jul 10.

CCR5 Δ32 minorallele is associated with susceptibility to SARS-CoV-2 infection and death: An epidemiological investigation

Affiliations

CCR5 Δ32 minorallele is associated with susceptibility to SARS-CoV-2 infection and death: An epidemiological investigation

Aditya K Panda et al. Clin Chim Acta. 2020 Nov.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Correlation of CCR-5 Δ32 minor allele prevalence with the number of COVID-19 infection cases/million and the number of patients death due to COVID-19/million worldwide. Prevalence of CCR-5 Δ32 mutant allele in healthy controls was searched from earlier published reports and correlated with COVID-19 infection (A) and death rate (B) per million throughout the globe. Each dot represented a country. A positive correlation was observed in the distribution of CCR-5 Δ32 minor allele with the number of cases (Spearman r = 0.4628, p < 0.0001, n = 107) and death (Spearman r = 0.5517, p < 0.0001, n = 107) from COVID-19. A total of one hundred seven countries were considered for the analysis based on availability of data. The list of countries are follows “Afghanistan, Albania, Algeria, Argentina, Armenia, Australia, Austria, Azerbaijan, Bahrain, Bangladesh, Belarus, Belgium, Bosnia and Herzegovina, Brazil, Bulgaria, Burkina Faso, Cameroon, Canada, Chile, China, Colombia, Croatia, Cuba, Cyprus, Czech Republic, DR Congo, Denmark, Dominican Republic, Ecuador, Egypt, El Salvador, Eritrea, Estonia, Ethiopia, Faeroe Islands, Finland, France, Georgia, Germany, Ghana, Greece, Guinea, Hong Kong, Hungary, India, Indonesia, Iran, Iraq, Ireland, Israel, Italy, Ivory Coast, Jamaica, Japan, Jordan, Kazakhstan, Kenya, Kosovo, Kyrgyzstan, Latvia, Lebanon, Lithuania, Luxembourg, Malawi, Malta, Mexico, Moldova, Mongolia, Montenegro, Morocco, Netherlands, New Zealand, Nigeria, Norway, Oman, Pakistan, Papua New Guinea, Peru, Philippines, Poland, Portugal, Romania, Russia, Rwanda, Saudi Arabia, Senegal, Serbia, Slovakia, Slovenia, Somalia, South Africa, South Korea, Spain, Sri Lanka, Sweden, Switzerland, Syria, Taiwan, Thailand, Tunisia, Turkey, Ukraine, United Arab Emirates, United Kingdom, United State, Venezuela, Vietnam”.

References

    1. Delanghe J.R., Speeckaert M.M., De Buyzere M.L. ACE Ins/Del genetic polymorphism and epidemiological findings in COVID-19. Clin. Chem. Lab. Med. 2020;58(7):1129–1130. - PubMed
    1. Klein R.S. A moving target: the multiple roles of CCR5 in infectious diseases. J. Infect. Dis. 2008;197(2):183–186. - PubMed
    1. Mummidi S., Ahuja S.S., McDaniel B.L., Ahuja S.K. The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J. Biol. Chem. 1997;272(49):30662–30671. - PubMed
    1. Solloch U.V., Lang K., Lange V., Bohme I., Schmidt A.H., Sauter J. Frequencies of gene variant CCR5-Delta32 in 87 countries based on next-generation sequencing of 1.3 million individuals sampled from 3 national DKMS donor centers. Hum. Immunol. 2017;78(11–12):710–717. - PubMed
    1. Nansen A., Christensen J.P., Andreasen S., Bartholdy C., Christensen J.E., Thomsen A.R. The role of CC chemokine receptor 5 in antiviral immunity. Blood. 2002;99(4):1237–1245. - PubMed

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