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Case Reports
. 2021 Jan;268(1):16-19.
doi: 10.1007/s00415-020-10057-5. Epub 2020 Jul 11.

Frontal encephalopathy related to hyperinflammation in COVID-19

Ilaria Cani #  1 , Valentina Barone #  1 , Roberto D'Angelo #  2 , Lara Pisani  3 , Vincenzo Allegri  4 , Luca Spinardi  5 , Paola Malpassi  6 , Luca Fasano  3 , Rita Rinaldi  7 , Stefano Fanti  4 , Pietro Cortelli  1   8 , Maria Guarino  7
Affiliations
Case Reports

Frontal encephalopathy related to hyperinflammation in COVID-19

Ilaria Cani et al. J Neurol. 2021 Jan.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Clinical symptoms, diagnostic work-up, treatment, and inflammatory profile during the disease course. CSF cerebrospinal fluid, ARDS acute respiratory distress syndrome, EEG electroencephalography, CT computed tomography, LP lumbar puncture, MRI magnetic resonance imaging, FDG-PET fluorodeoxyglucose-positron emission tomography, CRP C-reactive protein, IL-6 interleukin-6, IL-8 interleukin-8, TNFα tumor necrosis factor-alpha, IL-12 interleukin-12, IL-1β interleukin-1Beta, IL-10 interleukin-10; < , under limit of detection. Reference range: CRP < 0,50 mg/dl; ferritin 11–306 ng/ml; IL-6 < 5,9 pg/ml; IL-8 < 70 pg/ml; TNFα < 8,1 pg/ml, IL-10 < 9 pg/ml
Fig. 2
Fig. 2
Magnetic resonance imaging (MRI), 18F-FDG-PET/CT, and electroencephalography (EEG) findings. Normal MRI findings in MRI on T1 with gadolinium (a). 18F-FDG-PET/CT showing severe frontal lobe hypometabolism (b). EEG alterations observed at time of first neurologic evaluation with prominent and bilateral frontal slowing (c). Electroencephalographic acquisition settings: 10–20 system, longitudinal montage. Recording speed: 30 s/page; sensitivity: 7 μV/mm; time constant: 0.1 s; high-frequency filter: 70 Hz
See this image and copyright information in PMC

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