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. 2021 Jan;138(1):23-44.
doi: 10.1111/jbg.12496. Epub 2020 Jul 12.

Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle

Ludmilla C Brunes  1   2 , Fernando Baldi  3 , Fernando B Lopes  4 , Raysildo B Lôbo  5 , Rafael Espigolan  6 , Marcos F O Costa  2 , Nedenia B Stafuzza  7 , Cláudio U Magnabosco  8
Affiliations

Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle

Ludmilla C Brunes et al. J Anim Breed Genet. 2021 Jan.

Abstract

The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways (p-value < .05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste transduction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE-related traits.

Keywords: Bos indicus; GBLUP; residual body weight gain; residual feed intake; weighted single-step.

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