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Review
. 2020 Aug;36(2):303-322.
doi: 10.1016/j.cveq.2020.03.009.

Genetics of Equine Ocular Disease

Rebecca R Bellone  1
Affiliations
Review

Genetics of Equine Ocular Disease

Rebecca R Bellone. Vet Clin North Am Equine Pract. 2020 Aug.

Abstract

Horses perform in a variety of disciplines that are visually demanding, and any disease impacting the eye has the potential to threaten vision and thus the utility of the horse. Advances in equine genetics have enabled the understanding of some inherited ocular disorders and ocular manifestations and are enabling cross-species comparisons. Genetic testing for multiple congenital ocular anomalies, congenital stationary night blindness, equine recurrent uveitis, and squamous cell carcinoma can identify horses with or at risk for disease and thus can assist in clinical management and breeding decisions. This article describes the current knowledge of inherited ocular disorders.

Keywords: Genetics; Horses; Multiple congenital ocular anomalies; Night blindness; Ocular diseases; Ocular squamous cell carcinoma; Recurrent uveitis.

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Conflict of interest statement

Disclosure R.R. Bellone is affiliated with the Veterinary Genetics Laboratory, a genetic testing laboratory offering diagnostic tests in horses and other species. Genetic investigation of ERU in the Appaloosa was supported by the Morris Animal Foundation Grant D16EQ-028. The mission of the Morris Animal Foundation is to bridge science and resources to advance the health of animals. Investigation of the inherited risk for ocular SCC was supported by Morris Animal Foundation Grant D13EQ-808 and by UC Davis Center for Equine Health Grants with funds provided by the State of California Pari-Mutuel Fund and contributions by private donors.