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Review
. 2020 Jun 23:11:696.
doi: 10.3389/fphys.2020.00696. eCollection 2020.

Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity

Anna Gumà  1   2   3 , Francisco Díaz-Sáez  1   2   3 , Marta Camps  1   2   3 , Antonio Zorzano  1   2   4
Affiliations
Review

Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity

Anna Gumà et al. Front Physiol. .

Abstract

Various external factors modulate the metabolic efficiency of mitochondria. This review focuses on the impact of the growth factor neuregulin and its ErbB receptors on mitochondria and their relationship with several physiopathological alterations. Neuregulin is involved in the differentiation of heart, skeletal muscle, and the neuronal system, among others; and its deficiency is deleterious for the health. Information gathered over the last two decades suggests that neuregulin plays a key role in regulating the mitochondrial oxidative machinery, which sustains cell survival and insulin sensitivity.

Keywords: ErbB receptors; diabetes; insulin resistance; mitochondria; neuregulin; obesity.

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Figures

FIGURE 1
FIGURE 1
Protective actions of neuregulin on different tissues. Neuregulin, acting locally or as an endocrine factor, protects against metabolic stress and inflammation in a manner that is tightly linked to mitochondria function. Schematic art pieces used in this figure were provided by Servier Medical Art (http://servier.com/Powerpoint-image-bank). Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License.
See this image and copyright information in PMC

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