Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

doi:10.15698/cst2020.07.224

Review

. 2020 May 18;4(7):154-166.

doi: 10.15698/cst2020.07.224.

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Alejandra Gomez-Cadena^{1

2

3}, Alfonso Barreto³, Susana Fioretino³, Camilla Jandus^{1

2}

Affiliations

¹ Department of Pathology and Immunology, Targeting of Cytokine Secreting Lymphocyte group, Geneva University, Geneva, Switzerland.
² Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Switzerland.
³ Departamento de Microbiología, Grupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.

PMID: 32656498
PMCID: PMC7328673
DOI: 10.15698/cst2020.07.224

Review

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Alejandra Gomez-Cadena et al. Cell Stress. 2020.

. 2020 May 18;4(7):154-166.

doi: 10.15698/cst2020.07.224.

Authors

Alejandra Gomez-Cadena^{1

2

3}, Alfonso Barreto³, Susana Fioretino³, Camilla Jandus^{1

2}

Affiliations

¹ Department of Pathology and Immunology, Targeting of Cytokine Secreting Lymphocyte group, Geneva University, Geneva, Switzerland.
² Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Switzerland.
³ Departamento de Microbiología, Grupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.

PMID: 32656498
PMCID: PMC7328673
DOI: 10.15698/cst2020.07.224

Abstract

Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments. However, a promising field in the current therapies based on plant-derived compounds is the study of their immunomodulation properties and their capacity to activate the immune system to fight against multifactorial diseases like cancer. In this review we discuss how network pharmacology could help to characterize and validate natural single molecules or more complex preparations as promising cancer therapies based on their multitarget capacities.

Keywords: cancer; herbal medicine; immune response; immunogenic cell death; immunomodulation; natural products; network pharmacology.

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Conflict of interest statement

Conflict of interest: None of the authors declares any conflict of interest.

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References

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[1] Wang YJ, Fletcher R, Yu J, Zhang L. Immunogenic effects of chemotherapy-induced tumor cell death. Genes Dis. 2018;5(3):194–203. doi: 10.1016/j.gendis.2018.05.003. - DOI - PMC - PubMed

[2] Wang YJ, Fletcher R, Yu J, Zhang L. Immunogenic effects of chemotherapy-induced tumor cell death. Genes Dis. 2018;5(3):194–203. doi: 10.1016/j.gendis.2018.05.003. - DOI - PMC - PubMed

[3] Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008;4(11):682–690. doi: 10.1038/nchembio.118. - DOI - PubMed

[4] Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008;4(11):682–690. doi: 10.1038/nchembio.118. - DOI - PubMed

[5] Gertsch J. Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. Planta Med. 2011;77(11):1086–1098. doi: 10.1055/s-0030-1270904. - DOI - PubMed

[6] Gertsch J. Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. Planta Med. 2011;77(11):1086–1098. doi: 10.1055/s-0030-1270904. - DOI - PubMed

[7] Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochim Biophys Acta. 2013;1830(6):3670–3695. doi: 10.1016/j.bbagen.2013.02.008. - DOI - PMC - PubMed

[8] Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochim Biophys Acta. 2013;1830(6):3670–3695. doi: 10.1016/j.bbagen.2013.02.008. - DOI - PMC - PubMed

[9] Danciu Corina SC, Diana Antal, Popescu Alexandra, Ghiulai Roxana, Pavel Ioana Zinuca, Avram Stefana, Daliana Minda, Dehelean Cristina. An Update On Natural Compounds and Their Modern Formulations for the Management of Malignant Melanoma. In: Badria FA, editor. IntechOpen. Natural Products and Cancer Drug Discovery; 2017. p. 42. - DOI

[10] Danciu Corina SC, Diana Antal, Popescu Alexandra, Ghiulai Roxana, Pavel Ioana Zinuca, Avram Stefana, Daliana Minda, Dehelean Cristina. An Update On Natural Compounds and Their Modern Formulations for the Management of Malignant Melanoma. In: Badria FA, editor. IntechOpen. Natural Products and Cancer Drug Discovery; 2017. p. 42. - DOI

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Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Affiliations

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Authors

Affiliations

Abstract

Conflict of interest statement

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