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Case Reports
. 2020 Sep;41(9):2325-2329.
doi: 10.1007/s10072-020-04591-3. Epub 2020 Jul 12.

A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients

Davide Sangalli  1 , Valeria Polonia  2   3 , Daniele Colombo  2 , Vittorio Mantero  2 , Marco Filizzolo  4 , Chiara Scaccabarozzi  2 , Andrea Salmaggi  2
Affiliations
Case Reports

A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients

Davide Sangalli et al. Neurol Sci. 2020 Sep.

Abstract

The sudden worldwide outbreak of Coronavirus Disease 2019 (COVID-19) has certainly provided new challenges in the management of acute ischaemic stroke, and the risk-benefit ratio of intravenous thrombolysis in COVID-19 positive patients is not well known. We describe four COVID-19 patients treated with intravenous thrombolysis for acute ischaemic stroke. Although rt-PA administration is the main therapeutic strategy, our patients experienced unpredictable complications and showed atypical features: the overall mortality was very high. In conclusion, in this article, we provide information about these cases and discuss the possible explanation behind this trend.

Keywords: COVID-19; Intravenous thrombolysis; Stroke; rt-PA.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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