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Case Reports
. 2020 Oct;45(10):e439-e440.
doi: 10.1097/RLU.0000000000003199.

18F-FDG PET/CT in Labrune Syndrome

Marco Cuzzocrea  1 , Luigia Florimonte  1 , Elisa Scola  2 , Riccardo Benti  1 , Massimo Castellani  1
Affiliations
Case Reports

18F-FDG PET/CT in Labrune Syndrome

Marco Cuzzocrea et al. Clin Nucl Med. 2020 Oct.

Abstract

A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were observed at MRI and CT brain images. Generalized wave abnormalities were also visible at electroencephalogram. Functional brain imaging performed with F-FDG PET/CT demonstrated a decreased glucose metabolism in impaired brain regions, in accordance with MRI findings. Genetic testing confirmed a mutation of SNORD118.

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References

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