Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

doi:10.1097/INF.0000000000002815

Case Reports

. 2020 Sep;39(9):e265-e267.

doi: 10.1097/INF.0000000000002815.

Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

Julide Sisman¹, Mambarambath A Jaleel¹, Wilmer Moreno², Veena Rajaram³, Rebecca R J Collins³, Rashmin C Savani¹, Dinesh Rakheja³, Amanda S Evans⁴

Affiliations

¹ From the Division of Neonatal-Perinatal Medicine, Department of Pediatrics.
² Department of Obstetrics and Gynecology.
³ Department of Pathology.
⁴ Division of Infectious Diseases, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX.

PMID: 32658097
DOI: 10.1097/INF.0000000000002815

Case Reports

Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

Julide Sisman et al. Pediatr Infect Dis J. 2020 Sep.

. 2020 Sep;39(9):e265-e267.

doi: 10.1097/INF.0000000000002815.

Authors

Julide Sisman¹, Mambarambath A Jaleel¹, Wilmer Moreno², Veena Rajaram³, Rebecca R J Collins³, Rashmin C Savani¹, Dinesh Rakheja³, Amanda S Evans⁴

Affiliations

¹ From the Division of Neonatal-Perinatal Medicine, Department of Pediatrics.
² Department of Obstetrics and Gynecology.
³ Department of Pathology.
⁴ Division of Infectious Diseases, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX.

PMID: 32658097
DOI: 10.1097/INF.0000000000002815

Abstract

We present a preterm infant who developed a fever and mild respiratory disease on the second day of life. Infant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nasopharyngeal testing was positive at 24 and 48 hours of life. Placenta histopathology revealed SARS-CoV-2 infection by electron microscopy and immunohistochemistry. Further understanding of the risk factors that lead to in utero transmission of SARS-CoV-2 infection is needed.

PubMed Disclaimer

Comment in

SARS-COV-2 Maternal-Child Transmission: Can It Occur Before Delivery and How Do We Prove It?
Siberry GK, Reddy UM, Mofenson LM. Siberry GK, et al. Pediatr Infect Dis J. 2020 Sep;39(9):e263-e264. doi: 10.1097/INF.0000000000002820. Pediatr Infect Dis J. 2020. PMID: 32658094 No abstract available.

Cited by

Synthesis and systematic review of reported neonatal SARS-CoV-2 infections.
Raschetti R, Vivanti AJ, Vauloup-Fellous C, Loi B, Benachi A, De Luca D. Raschetti R, et al. Nat Commun. 2020 Oct 15;11(1):5164. doi: 10.1038/s41467-020-18982-9. Nat Commun. 2020. PMID: 33060565 Free PMC article.
COVID-19: Neurological Considerations in Neonates and Children.
Stafstrom CE, Jantzie LL. Stafstrom CE, et al. Children (Basel). 2020 Sep 10;7(9):133. doi: 10.3390/children7090133. Children (Basel). 2020. PMID: 32927628 Free PMC article. Review.
Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) including Variant Analysis by Mass Spectrometry in Placental Tissue.
Wierz M, Sauerbrei B, Wandernoth P, Kriegsmann M, Casadonte R, Kriegsmann K, Kriegsmann J. Wierz M, et al. Viruses. 2022 Mar 14;14(3):604. doi: 10.3390/v14030604. Viruses. 2022. PMID: 35337011 Free PMC article.
Maternal COVID-19 exposure and placental characteristics.
Allo G, Sitarik AR, Redding A, Coleman CM, Cassidy-Bushrow AE, Gaba A, Straughen JK. Allo G, et al. PLoS One. 2024 May 23;19(5):e0302682. doi: 10.1371/journal.pone.0302682. eCollection 2024. PLoS One. 2024. PMID: 38781150 Free PMC article.
Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS).
Mao Q, Chu S, Shapiro S, Bliss JM, De Paepe ME. Mao Q, et al. Placenta. 2021 Feb;105:7-13. doi: 10.1016/j.placenta.2021.01.008. Epub 2021 Jan 15. Placenta. 2021. PMID: 33497931 Free PMC article.

See all "Cited by" articles

References

1. Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020. doi: 10.5858/arpa.2020-0901-SA. [Epub ahead of print] - DOI
1. Zeng L, Xia S, Yuan W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr. 2020;e200878. [Epub ahead of print]
1. Zamaniyan M, Ebadi A, Aghajanpoor Mir S, et al. Preterm delivery in pregnant woman with critical COVID-19 pneumonia and vertical transmission. Prenat Diagn. 2020. doi: 10.1002/pd.5713. [Epub ahead of print] - DOI
1. Alzamora MC, Paredes T, Caceres D, et al. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020;37:861–865.
1. Kirtsman M, Diambomba Y, Poutanen SM, et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ. 2020;192:E647–E650.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020. doi: 10.5858/arpa.2020-0901-SA. [Epub ahead of print] - DOI

[2] Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020. doi: 10.5858/arpa.2020-0901-SA. [Epub ahead of print] - DOI

[3] Zeng L, Xia S, Yuan W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr. 2020;e200878. [Epub ahead of print]

[4] Zeng L, Xia S, Yuan W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr. 2020;e200878. [Epub ahead of print]

[5] Zamaniyan M, Ebadi A, Aghajanpoor Mir S, et al. Preterm delivery in pregnant woman with critical COVID-19 pneumonia and vertical transmission. Prenat Diagn. 2020. doi: 10.1002/pd.5713. [Epub ahead of print] - DOI

[6] Zamaniyan M, Ebadi A, Aghajanpoor Mir S, et al. Preterm delivery in pregnant woman with critical COVID-19 pneumonia and vertical transmission. Prenat Diagn. 2020. doi: 10.1002/pd.5713. [Epub ahead of print] - DOI

[7] Alzamora MC, Paredes T, Caceres D, et al. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020;37:861–865.

[8] Alzamora MC, Paredes T, Caceres D, et al. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020;37:861–865.

[9] Kirtsman M, Diambomba Y, Poutanen SM, et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ. 2020;192:E647–E650.

[10] Kirtsman M, Diambomba Y, Poutanen SM, et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ. 2020;192:E647–E650.

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

Affiliations

Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

Authors

Affiliations

Abstract

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous