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. 2020 Oct:284:113925.
doi: 10.1016/j.jviromet.2020.113925. Epub 2020 Jul 10.

Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay

Daniel Goldenberger  1 , Karoline Leuzinger  2 , Kirstine K Sogaard  3 , Rainer Gosert  2 , Tim Roloff  3 , Klaudia Naegele  2 , Aline Cuénod  4 , Alfredo Mari  4 , Helena Seth-Smith  3 , Katharina Rentsch  5 , Vladimira Hinić  1 , Hans H Hirsch  6 , Adrian Egli  7
Affiliations

Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay

Daniel Goldenberger et al. J Virol Methods. 2020 Oct.

Abstract

The clinical and epidemiologic management of the SARS-CoV-2 pandemic is critically dependent on molecular assays with short turn-around time. We validated the novel Xpert Xpress SARS-CoV-2 assay using a commercial nucleic acid testing (Roche Cobas 6800). We found an excellent concordance over a range of SARS-CoV-2 loads and across established human coronaviruses.

Keywords: COBAS 6800; COVID-19; Diagnostics; GeneXpert; NAT; PCR; Respiratory infection; SARS-CoV-2; Viruses.

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Conflict of interest statement

All authors report no conflicts of interest relevant to this article.

Figures

Fig. 1
Fig. 1
Correlation of Ct-values between different assays and targeted viral genes for the n = 10 positive samples. Formula for best fit linear curve is shown (Graph Pad Prism version 8.4.0). Linear regression analysis was used to calculate R (O’Connell et al., 2020).
See this image and copyright information in PMC

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