Letter to the Editor - Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report

doi:10.1016/j.pcad.2020.07.006

Comment

. 2020 Sep-Oct;63(5):702-703.

doi: 10.1016/j.pcad.2020.07.006. Epub 2020 Jul 10.

Letter to the Editor - Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report

Brandon Michael Henry¹, Stefanie Benoit², Giuseppe Lippi³, Justin Benoit⁴

Affiliations

¹ Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: brandon.henry@cchmc.org.
² Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, OH, USA; Department of Pediatrics, University of Cincinnati, College of Medicine, OH, USA.
³ Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.
⁴ Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA.

PMID: 32659343
PMCID: PMC7348599
DOI: 10.1016/j.pcad.2020.07.006

Comment

Letter to the Editor - Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report

Brandon Michael Henry et al. Prog Cardiovasc Dis. 2020 Sep-Oct.

. 2020 Sep-Oct;63(5):702-703.

doi: 10.1016/j.pcad.2020.07.006. Epub 2020 Jul 10.

Authors

Brandon Michael Henry¹, Stefanie Benoit², Giuseppe Lippi³, Justin Benoit⁴

Affiliations

¹ Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: brandon.henry@cchmc.org.
² Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, OH, USA; Department of Pediatrics, University of Cincinnati, College of Medicine, OH, USA.
³ Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.
⁴ Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA.

PMID: 32659343
PMCID: PMC7348599
DOI: 10.1016/j.pcad.2020.07.006

No abstract available

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Figures

**Fig. 1**
Comorbidities of included COVID-19 patients (A). Plasma angiotensin 2 (AngII) and aldosterone levels were comparable in patients with COVID-19 versus healthy controls (B,C). AngII concentrations were similar between COVID-19 patients requiring ICU admission vs. those not requiring ICU admission (D). AngII levels significantly correlated with aldosterone levels in the COVID-19 cohort (p = 0.03) (E).

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Comment on

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.
Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Li J, Feng C, Zhang Z, Wang L, Peng L, Chen L, Qin Y, Zhao D, Tan S, Yin L, Xu J, Zhou C, Jiang C, Liu L. Liu Y, et al. Sci China Life Sci. 2020 Mar;63(3):364-374. doi: 10.1007/s11427-020-1643-8. Epub 2020 Feb 9. Sci China Life Sci. 2020. PMID: 32048163 Free PMC article.

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References

1. Sanchis-Gomar F., Lavie C.J., Perez-Quilis C., Henry B.M., Lippi G. Angiotensin-converting enzyme 2 and anti-hypertensives (angiotensin receptor blockers and angiotensin converting enzyme inhibitors) in coronavirus disease 2019 (COVID-19) Mayo Clin Proc. 2020;19 - PMC - PubMed
1. Henry B.M., Vikse J. Clinical characteristics of Covid-19 in China. N Engl J Med. 2020;382 - PubMed
1. Kuba K., Imai Y., Rao S. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005;11:875–879. - PMC - PubMed
1. Liu Y., Yang Y., Zhang C. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63:364–374. - PMC - PubMed
1. South A.M., Diz D.I., Chappell M.C. COVID-19, ACE2, and the cardiovascular consequences. Am J Physiol Heart Circ Physiol. 2020;318:H1084–H1090. - PMC - PubMed

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[1] Sanchis-Gomar F., Lavie C.J., Perez-Quilis C., Henry B.M., Lippi G. Angiotensin-converting enzyme 2 and anti-hypertensives (angiotensin receptor blockers and angiotensin converting enzyme inhibitors) in coronavirus disease 2019 (COVID-19) Mayo Clin Proc. 2020;19 - PMC - PubMed

[2] Sanchis-Gomar F., Lavie C.J., Perez-Quilis C., Henry B.M., Lippi G. Angiotensin-converting enzyme 2 and anti-hypertensives (angiotensin receptor blockers and angiotensin converting enzyme inhibitors) in coronavirus disease 2019 (COVID-19) Mayo Clin Proc. 2020;19 - PMC - PubMed

[3] Henry B.M., Vikse J. Clinical characteristics of Covid-19 in China. N Engl J Med. 2020;382 - PubMed

[4] Henry B.M., Vikse J. Clinical characteristics of Covid-19 in China. N Engl J Med. 2020;382 - PubMed

[5] Kuba K., Imai Y., Rao S. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005;11:875–879. - PMC - PubMed

[6] Kuba K., Imai Y., Rao S. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005;11:875–879. - PMC - PubMed

[7] Liu Y., Yang Y., Zhang C. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63:364–374. - PMC - PubMed

[8] Liu Y., Yang Y., Zhang C. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63:364–374. - PMC - PubMed

[9] South A.M., Diz D.I., Chappell M.C. COVID-19, ACE2, and the cardiovascular consequences. Am J Physiol Heart Circ Physiol. 2020;318:H1084–H1090. - PMC - PubMed

[10] South A.M., Diz D.I., Chappell M.C. COVID-19, ACE2, and the cardiovascular consequences. Am J Physiol Heart Circ Physiol. 2020;318:H1084–H1090. - PMC - PubMed

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Letter to the Editor - Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report

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Letter to the Editor - Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report

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