Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2020 Jul 9;12(7):2033.
doi: 10.3390/nu12072033.

Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

Cynthia El Hajj  1   2 , Stéphane Walrand  2 , Mariana Helou  3 , Kaissar Yammine  4
Affiliations
Randomized Controlled Trial

Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

Cynthia El Hajj et al. Nutrients. .

Abstract

Background: A low serum 25-hydroxyvitamin D (25(OH) D) concentration has been associated with a higher risk of type 2 diabetes mellitus (T2DM), especially in older people. Our aim in this randomized controlled trial was to evaluate the effect of vitamin D treatment on inflammatory markers in non-obese Lebanese patients with T2DM, living in Beirut, Lebanon.

Methods: Non-Obese patients with T2DM (n = 88), deficient/insufficient in vitamin D, were randomly assigned into one of two groups-a treatment group receiving 30,000 IU cholecalciferol/week for a period of six months, and a placebo group. Serum concentrations of TNF-α, high-sensitivity C-reactive protein (hs-CRP), and Interleukin-6 (IL-6) were the primary outcomes. A homeostatic model of insulin resistance (HOMA-IR) was assessed, in addition to serum concentrations of fasting blood glucose (FBG), HbA1C, (25(OH) D), and PTH.

Results: The vitamin D group showed higher blood levels of (25(OH) D) (p < 0.0001), and a significant reduction in hs-CRP and TNF-α concentrations (p < 0.0001) compared to placebo. The decrease perceived in IL-6 concentrations was not significant (p = 0.1). No significant changes were seen in FBG (p = 0.9) and HbA1c levels (p = 0.85).

Conclusion: Six months of vitamin D supplementation led to a decrease in some inflammatory markers in patients with T2DM. Additional studies with a larger sample and a longer period are advised in this regard. This trial was registered at ClinicalTrial.gov; Identifier number: NCT03782805.

Keywords: IL-6; TNF-α; hs-CRP; type 2 diabetes mellitus; vitamin D.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
CONSORT flow diagram.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bland R., Markovic D., Hill C.E., Hughes S. Expression of 25-hydroxyvitamin D3-1 alpha-hydroxylase in pancreatic islets. J. Steroid Biochem. Mol. Biol. 2004;121:89–90. doi: 10.1016/S0960-0760(04)00149-9. - DOI - PubMed
    1. Khalife H., Khalife H., Omyri H., Khalife H., Abdel-Sater F. Vitamin D deficiency among the healthy population in Lebanon. World J. Pharm. Pharm. Sci. 2017;6647:69–80.
    1. El-Rassi R., Baliki G., Fulheihan G.E.H. Vitanim D Status in Middle East and Africa. American University of Beirut Medical Center, Department of Internal Medicine and International Osteoporosis Foundation; Beirut, Lebanon: 2009.
    1. International Diabetes Federation: IDF Diabetes Atlas. [(accessed on 5 January 2020)];2019 Available online: https://www.diabetesatlas.org/upload/resources/2019/IDFAtlas9th_Edition_....
    1. Sepehri Z., Kiani Z., Afshari M., Kohan F., Dalvand A., Ghavami S. Inflammasomes and type 2 diabetes: An updated systemic review. Immunol. Lett. 2017;24:97–103. doi: 10.1016/j.imlet.2017.10.010. - DOI - PubMed

Publication types

Associated data