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Review
. 2020 Jul 9;10(7):1017.
doi: 10.3390/biom10071017.

The Regulatory Role of IL-10 in Neurodegenerative Diseases

Chiara Porro  1 , Antonia Cianciulli  2 , Maria Antonietta Panaro  2
Affiliations
Review

The Regulatory Role of IL-10 in Neurodegenerative Diseases

Chiara Porro et al. Biomolecules. .

Abstract

IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory modulator of glial activation, preventing inflammation-mediated neuronal degeneration under pathological conditions. In this narrative review, we summarize recent insights about the role of IL-10 in the neurodegeneration associated with neuroinflammation, in diseases such as Multiple Sclerosis, Traumatic Brain Injury, Amyotrophic lateral sclerosis, Alzheimer's Disease, and Parkinson's Disease, focusing on the contribution of this cytokine not only in terms of protective action, but also as possibly responsible for clinical worsening. The knowledge of this double face of the same coin, regarding the biological role of the IL-10, could aid the development of targeted therapies useful for limiting neurodegenerative processes.

Keywords: IL-10; microglia; neurodegeneration; neuroinflammation; signaling.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scheme illustrating the IL-10 signaling pathway.
Figure 2
Figure 2
Potential therapeutic actions of IL-10 in neurodegenerative diseases.
See this image and copyright information in PMC

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