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. 1988;17(6):469-74.
doi: 10.3109/03009748809098809.

Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases

A J Swaak  1 , A van Rooyen, E Nieuwenhuis, L A Aarden
Affiliations

Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases

A J Swaak et al. Scand J Rheumatol. 1988.

Abstract

Interleukin-6 (IL-6) is a monokine with a number of biological activities, which are intimately related to inflammatory responses. We have measured IL-6 levels in synovial fluid (SF) and serum (Se) of patients with rheumatic diseases. SF-IL-6 levels were a thousand-fold higher than corresponding Se levels and a positive correlation was found between SF and Se levels suggesting that Se-IL-6 is derived from IL-6 produced in the joint. Se levels of IL-6 were also positively correlated to C-reactive protein (CRP) levels, supporting the in vitro experiments showing that IL-6 stimulates hepatocytes to produce CRP. Finally we observed a positive correlation between SF-IL-6 levels and the local activity score.

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