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. 2020 Jul 13;20(1):223.
doi: 10.1186/s12876-020-01354-4.

The diffuse-type gastric cancer epidemiology enigma

Paulo Pimentel Assumpção  1 , Williams Fernandes Barra  2 , Geraldo Ishak  3 , Luiz Gonzaga Vaz Coelho  4 , Felipe José Fernandez Coimbra  5 , Helano Carioca Freitas  6 , Emmanuel Dias-Neto  7 , M Constanza Camargo  8 , Moyses Szklo  9
Affiliations

The diffuse-type gastric cancer epidemiology enigma

Paulo Pimentel Assumpção et al. BMC Gastroenterol. .

Abstract

Background: Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated.

Results: Besides its growing importance, there are many gaps about the diffuse-type carcinogenesis and, as a result, its epidemiologic and pathogenetic features remain poorly understood.

Conclusions: Alternative hypotheses to explain these features are discussed, including the role of the gastric microbiota, medical therapies, and modifications in the stomach's microenvironment.

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Conflict of interest statement

none of the authors have any competing interests.

Figures

Fig. 1
Fig. 1
Hypothesis to explain the continuing stable incidence of diffuse-type gastric cancer
Fig. 2
Fig. 2
The microbiota favors the evolution to either peptic disease or gastric cancer
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataran I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019;14(1):26–28. - PMC - PubMed
    1. Waldum HL, Fossmark R. Types of gastric carcinomas. Int J Mol Sci. 2018;19(12):4109. doi: 10.3390/ijms19124109. - DOI - PMC - PubMed
    1. Wu H, Rusiecki JA, Zhu K, Potter J, Devesa SS. Stomach carcinoma incidence patterns in the United States by histologic type and anatomic site. Cancer Epidemiol Biomark Prev. 2009;18(7):1945–1952. doi: 10.1158/1055-9965.EPI-09-0250. - DOI - PMC - PubMed
    1. Wachtel MS, Zhang Y, Chiriva-Internati M, Frezza EE. Different regression equations relate age to the incidence of Lauren types 1 and 2 stomach cancer in the SEER database: these equations are unaffected by sex or race. BMC Cancer. 2006;6:65. doi: 10.1186/1471-2407-6-65. - DOI - PMC - PubMed