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. 2020 Sep;20(9):522-528.
doi: 10.1038/s41577-020-0374-6. Epub 2020 Jul 13.

Can we harness the microbiota to enhance the efficacy of cancer immunotherapy?

B Brett Finlay  1   2   3 , Romina Goldszmid  4 , Kenya Honda  5   6 , Giorgio Trinchieri  7 , Jennifer Wargo  8   9 , Laurence Zitvogel  10   11   12   13
Affiliations

Can we harness the microbiota to enhance the efficacy of cancer immunotherapy?

B Brett Finlay et al. Nat Rev Immunol. 2020 Sep.

Abstract

There is currently much interest in defining how the microbiota shapes immune responses in the context of cancer. Various studies in both mice and humans have associated particular commensal species with better (or worse) outcomes in different cancer types and following treatment with cancer immunotherapies. However, the mechanisms involved remain ill-defined and even controversial. In this Viewpoint, Nature Reviews Immunology has invited six eminent scientists in the field to share their thoughts on the key questions and challenges for the field.

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References

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