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. 2020 Dec;258(12):2671-2679.
doi: 10.1007/s00417-020-04832-3. Epub 2020 Jul 13.

Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography

Naiqiang Xie  1 , Yan Tan  2 , Sen Liu  2 , Yining Xie  1 , Shaoshuai Shuai  1 , Wei Wang  3 , Wenyong Huang  4
Affiliations

Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography

Naiqiang Xie et al. Graefes Arch Clin Exp Ophthalmol. 2020 Dec.

Abstract

Purpose: Previous studies on the association between macular vessel density (VD) and diabetic retinopathy had conflicting conclusions. This study assessed the alterations of macular VD, as well as other factors, in diabetic patients using swept-source optical coherence tomography angiography (SS-OCTA) in a large-scale sample from Chinese communities.

Methods: Patients with type 2 diabetes without history of ocular treatment were recruited from 2017 to 2018. The average and quadrant parafoveal vessel density (PVD) were obtained with a commercial SS-OCTA device (Triton, Topcon, Japan). The univariate and multivariate linear regression was used to analyse the correlation of PVD with diabetic retinopathy (DR), diabetic macular edema (DME), HbA1c, and other factors.

Results: A total of 919 patients were included in the final statistical analysis. After adjusting for other confounding factors, the DR patients had significantly lower average PVD (β = - 1.062, 95% CI = - 1.424 to - 0.699, P < 0.001) in comparison with those without DR. In addition, the patients with mild DR or vision-threatening diabetic retinopathy (VTDR) also had significantly lower PVD (P < 0.001 for mild DR, and P = 0.008 for VTDR) compared with those without DR. Age and HbA1c were also significantly related to PVD measurements, as shown by multivariable linear regression. Participants with DME had a significantly lower average PVD and temporal PVD than those without DME (P < 0.05).

Conclusions: Reduced PVD was independently associated with more severe DR, older age, higher HbA1c level, and the presence of DME. These findings suggested that macular vessel alterations in DR warrant further evaluation in the longitudinal studies.

Keywords: Diabetic retinopathy; OCTA; Swept-source; Vessel density.

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References

    1. Wong TY, Cheung CM, Larsen M et al (2016) Diabetic retinopathy. Nat Rev Dis Primers 2:16012 - DOI
    1. Stitt AW, Curtis TM, Chen M et al (2016) The progress in understanding and treatment of diabetic retinopathy. Prog Retin Eye Res 51:156–186 - DOI
    1. Cheung CY, Ikram MK, Klein Ret al. (2015) The clinical implications of recent studies on the structure and function of the retinal microvasculature in diabetes. Diabetologia 58(5):871–885 - DOI
    1. Lee J, Rosen R (2016) Optical coherence tomography angiography in diabetes. Curr Diab Rep 16(12):123 - DOI
    1. Khadamy J, Abri AK, Falavarjani KG (2018) An update on optical coherence tomography angiography in diabetic retinopathy. J Ophthalmic Vis Res 13(4):487–497 - DOI

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