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. 2020 Oct;140(4):591-593.
doi: 10.1007/s00401-020-02192-0. Epub 2020 Jul 13.

Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex

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Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex

Gabor G Kovacs et al. Acta Neuropathol. 2020 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1
GFAs in PDC (a, b; arrows). Subpial TSAs in the frontal cortex (c) showing focal accumulations at the surface (arrow). TSAs accumulate in the white matter (d). Subpial TSAs in the depth of sulci (e–h), associated occasionally with gray matter GFAs (e: arrows; g: box enlarged in h), without perivascular neuronal tangles. TSAs surrounding well-preserved motor neurons of the cervical spinal cord (i) and in the dentate gyrus (j). Scale bar in “a” represents 15 μm for a, b; 25 μm for i, j; 100 μm for e–g; 30 μm for c; 50 μm for h; and 250 μm for d

References

    1. Forrest SL, Kril JJ, Wagner S, Honigschnabl S, Reiner A, Fischer P et al. (2019) Chronic traumatic encephalopathy (CTE) is absent from a european community-based aging cohort while cortical aging-related tau astrogliopathy (ARTAG) is highly prevalent. J Neuropathol Exp Neurol 78:398–405. 10.1093/jnen/nlz017 - DOI - PubMed
    1. Hof PR, Perl DP, Loerzel AJ, Morrison JH (1991) Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer’s disease. Brain Res 564:306–313. 10.1016/0006-8993(91)91467-f - DOI - PubMed
    1. Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA et al. (2017) Evaluating the patterns of aging-related tau astrogliopathy unravels novel insights into brain aging and neurodegenerative diseases. J Neuropathol Exp Neurol 76:270–288. 10.1093/jnen/nlx007 - DOI - PMC - PubMed
    1. McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I et al. (2016) The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol 131:75–86. 10.1007/s00401-015-1515-z - DOI - PMC - PubMed
    1. Shimizu H, Kakita A, Takahashi H (2008) Spinal cord tau pathology in cervical spondylotic myelopathy. Acta Neuropathol 115:185–192. 10.1007/s00401-007-0321-7 - DOI - PubMed

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