Cytotoxic CD4⁺ T Cells in Bladder Cancer-A New License to Kill

Adrian G Sacher¹, Michael St Paul¹, Christopher J Paige¹, Pamela S Ohashi²

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network, 610 University Ave., Toronto, ON M5G 2M9, Canada; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
² Princess Margaret Cancer Centre, University Health Network, 610 University Ave., Toronto, ON M5G 2M9, Canada; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: pam.ohashi@uhnresearch.ca.

PMID: 32663467
DOI: 10.1016/j.ccell.2020.06.013

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Cytotoxic CD4⁺ T Cells in Bladder Cancer-A New License to Kill

Adrian G Sacher et al. Cancer Cell. 2020.

Free article

. 2020 Jul 13;38(1):28-30.

doi: 10.1016/j.ccell.2020.06.013.

Authors

Adrian G Sacher¹, Michael St Paul¹, Christopher J Paige¹, Pamela S Ohashi²

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network, 610 University Ave., Toronto, ON M5G 2M9, Canada; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
² Princess Margaret Cancer Centre, University Health Network, 610 University Ave., Toronto, ON M5G 2M9, Canada; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: pam.ohashi@uhnresearch.ca.

PMID: 32663467
DOI: 10.1016/j.ccell.2020.06.013

Abstract

CD4⁺ T cells with cytotoxic capability are increasingly recognized as potentially key actors in anti-tumor immunity. A new report in Cell elucidates the presence and potential role of a population of cytotoxic CD4⁺ T cells in bladder cancer using single cell sequencing technology.

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Intratumoral CD4⁺ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.
Oh DY, Kwek SS, Raju SS, Li T, McCarthy E, Chow E, Aran D, Ilano A, Pai CS, Rancan C, Allaire K, Burra A, Sun Y, Spitzer MH, Mangul S, Porten S, Meng MV, Friedlander TW, Ye CJ, Fong L. Oh DY, et al. Cell. 2020 Jun 25;181(7):1612-1625.e13. doi: 10.1016/j.cell.2020.05.017. Epub 2020 Jun 3. Cell. 2020. PMID: 32497499 Free PMC article.

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Cytotoxic CD4⁺ T Cells in Bladder Cancer-A New License to Kill

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Cytotoxic CD4⁺ T Cells in Bladder Cancer-A New License to Kill

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Medical

Research Materials