Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul 10;13(7):148.
doi: 10.3390/ph13070148.

A Pilot Study of a Natural Food Supplement as New Possible Therapeutic Approach in Chronic Kidney Disease Patients

Annalisa Noce  1 , Alessio Bocedi  2 , Margherita Campo  3 , Giulia Marrone  1   4 , Manuela Di Lauro  1 , Giada Cattani  2 , Nicola Di Daniele  1 , Annalisa Romani  3
Affiliations

A Pilot Study of a Natural Food Supplement as New Possible Therapeutic Approach in Chronic Kidney Disease Patients

Annalisa Noce et al. Pharmaceuticals (Basel). .

Abstract

The identification of natural bioactive compounds, able to counteract the abnormal increase of oxidative stress and inflammatory status in chronic degenerative non-communicable diseases is useful for the clinical management of these conditions. We tested an oral food supplement (OFS), chemically characterized and evaluated for in vitro and in vivo activity. Vitamin C, analyzed by High Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD), was 0.19 mg/g in rosehip dry extract and 15.74 mg/capsule in the OFS. The identification of polyphenols was performed by HPLC-DAD; the total antioxidant capacity was assessed by Folin-Ciocalteu test. Total polyphenols were 14.73 mg/g gallic acid equivalents (GAE) for rosehip extract and 1.93 mg/g GAE for OFS. A total of 21 chronic kidney disease (CKD) patients and 10 healthy volunteers were recruited. The evaluation of routine laboratory and inflammatory parameters, erythrocyte glutathione transferase (e-GST), human oxidized serum albumin (HSAox), and assessment of body composition were performed at two different times, at baseline and after 5 weeks of OFS assumption. In the study, we highlighted a significant decrease of traditional inflammatory biomarkers (such as C-reactive protein, erythrocyte sedimentation rate, platelet to lymphocyte ratio) and other laboratory parameters like e-GST, azotaemia, and albuminuria after OFS treatment in CKD patients. Moreover, we demonstrated a lipid profile improvement in CKD patients after OFS supplementation.

Keywords: bioactive compounds; conservative therapy; erythrocyte glutathione transferase; human oxidized serum albumin; inflammatory biomarkers; natural antioxidants; vitamin C.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Human oxidized serum albumin in chronic kidney disease patients. The bars (five shades of grey) represent the values HSAox determined at various times (T0, 1 week, 2 weeks, 3 weeks, and 5 weeks—T1) for CKD patients (N = 21). Values are reported as mean ± standard deviation.
Figure 2
Figure 2
Pharmacological therapy on calcium-phosphorus metabolism.
See this image and copyright information in PMC

References

    1. Bruck K., Stel V.S., Gambaro G., Hallan S., Volzke H., Arnlov J., Kastarinen M., Guessous I., Vinhas J., Stengel B., et al. CKD Prevalence Varies across the European General Population. J. Am. Soc. Nephrol. 2016;27:2135–2147. doi: 10.1681/ASN.2015050542. - DOI - PMC - PubMed
    1. Vassalotti J.A., Fox C.H., Becker B.N. Risk factors and screening for chronic kidney disease. Adv. Chronic Kidney Dis. 2010;17:237–245. doi: 10.1053/j.ackd.2010.03.003. - DOI - PubMed
    1. Foley R.N., Parfrey P.S., Harnett J.D., Kent G.M., Murray D.C., Barre P.E. Hypoalbuminemia, cardiac morbidity, and mortality in end-stage renal disease. J. Am. Soc. Nephrol. 1996;7:728–736. - PubMed
    1. Eddington H., Hoefield R., Sinha S., Chrysochou C., Lane B., Foley R.N., Hegarty J., New J., O’Donoghue D.J., Middleton R.J., et al. Serum phosphate and mortality in patients with chronic kidney disease. Clin. J. Am. Soc. Nephrol. 2010;5:2251–2257. doi: 10.2215/CJN.00810110. - DOI - PMC - PubMed
    1. Dessi M., Noce A., Agnoli A., De Angelis S., Fuiano L., Tozzo C., Taccone-Gallucci M., Fuiano G., Federici G. The usefulness of the prognostic inflammatory and nutritional index (PINI) in a haemodialysis population. Nutr. Metab. Cardiovasc. Dis. 2009;19:811–815. doi: 10.1016/j.numecd.2009.01.009. - DOI - PubMed