Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct;59(12):1086-1091.
doi: 10.1177/0009922820941247. Epub 2020 Jul 15.

Incidence of Celiac Disease in Down Syndrome: A Longitudinal, Population-Based Birth Cohort Study

Kathryn K Ostermaier  1 , Amy L Weaver  2 , Scott M Myers  3 , Ruth E Stoeckel  2 , Slavica K Katusic  2 , Robert G Voigt  1
Affiliations

Incidence of Celiac Disease in Down Syndrome: A Longitudinal, Population-Based Birth Cohort Study

Kathryn K Ostermaier et al. Clin Pediatr (Phila). 2020 Oct.

Abstract

American Academy of Pediatrics (AAP) guidelines for children with Down syndrome (DS) include assessment for celiac disease (CD), although data to support this recommendation have been inconsistent. We determined the incidence of CD among children with DS in a population-based birth cohort of children born from 1976 to 2000 in Olmsted County, Minnesota. Individuals with karyotype-confirmed DS and CD (using diagnosis codes, positive serology, and duodenal biopsies) were identified. The incidence of CD in DS was compared with the published incidence of CD for Olmsted County residents (17.4 [95% confidence interval = 15.2-19.6] per 100 000 person-years). Among 45 individuals with DS from the birth cohort, 3 (6.7%) were identified with positive celiac serology and confirmatory biopsies at ages 9, 12, and 23 years, for an incidence of 325 per 100 000 person-years. Thus, individuals with DS have more than 18 times the incidence rate of CD compared with the general population, supporting the AAP guidelines.

Keywords: Down syndrome; celiac disease; trisomy 21.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Besser LM, Shin M, Kucik JE, Correa A. Prevalence of Down syndrome among children and adolescents in metropolitan Atlanta. Birth Defects Res A Clin Mol Teratol. 2007;79:765–774. - PubMed
    1. van Gameren-Oosterom HBM, Buitendijk SE, Bilardo CM, van der Pal-de Bruin KM, Van Wouwe JP, Mohangoo AD. Unchanged prevalence of Down syndrome in the Netherlands: results from an 11-year nationwide birth cohort. Prenat Diagn. 2012;32:1035–1040. - PubMed
    1. Egan JFX, Benn PA, Zelop CM, Bolnick A, Gianferrari E, Borgida AF. Down syndrome births in the United States from 1989 to 2001. Am J Obstet Gynecol. 2004;191: 1044–1048. - PubMed
    1. Presson AP, Partyka G, Jensen KM, et al. Current estimate of Down syndrome population prevalence in the United States. J Pediatr. 2013;163:1163–1168. - PMC - PubMed
    1. Parker SE, Mai CT, Canfield MA, et al. Updated national birth prevalence estimates for selected birth defects in the United States, 2004–2006. Birth Defects Res A Clin Mol Teratol. 2010;88:1008–1016. - PubMed

Publication types