Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun 30:2020:2856460.
doi: 10.1155/2020/2856460. eCollection 2020.

Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints

Lars M Berg  1 , Torun K S Ankjell  2   3 , Yi-Qian Sun  4   5 , Tordis A Trovik  6 , Oddveig G Rikardsen  2   3 , Anders Sjögren  1 , Ketil Moen  7 , Sølve Hellem  8 , Vegard Bugten  9   10
Affiliations

Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints

Lars M Berg et al. Int J Otolaryngol. .

Erratum in

Abstract

In this randomized controlled trial, patients with nonsevere obstructive sleep apnea (OSA) were treated with continuous positive airway pressure (CPAP) or a twin block mandibular advancement splint (MAS). The primary objective was to compare how CPAP and MAS treatments change the health-related quality of life (HRQoL) and self-reported sleep quality of patients after 12 months of treatment. In total, 104 patients were recruited: 55 were allocated to the CPAP treatment group and 49 to the MAS treatment group. We used the SF36 questionnaire to evaluate HRQoL and the Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality. All patients were included in the intention-to-treat analyses. These analyses showed improvements in the SF36 physical component score (from 48.8 ± 7.6 at baseline to 50.5 ± 8.0 at follow-up, p=0.03) in the CPAP treatment group and in the mental component score (from 44.9 ± 12.1 to 49.3 ± 9.2, p=0.009) in the MAS treatment group. The PSQI global score improved in both the CPAP (from 7.7 ± 3.5 to 6.6 ± 2.9, p=0.006) and the MAS (8.0 ± 3.1 to 6.1 ± 2.6, p < 0.001) treatment groups. No difference was found between the treatment groups in any of the SF36 scores or PSQI global score at the final follow-up (p > 0.05) in any analysis. The improvement in the SF36 vitality domain moderately correlated to the improvement in the PSQI global score in both groups (CPAP: |r|=0.47, p < 0.001; MAS: |r|=0.36, p=0.01). In the MAS treatment group, we also found a weak correlation between improvements in the SF36 mental component score and PSQI global score (|r|=0.28, p=0.05). In conclusion, CPAP and MAS treatments lead to similar improvements in the HRQoL and self-reported sleep quality in nonsevere OSA. Improvements in aspects of HRQoL seem to be moderately correlated to the self-reported sleep quality in both CPAP and MAS treatments.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Patient flowchart.
See this image and copyright information in PMC

References

    1. Lacasse Y., Godbout C., Series F. Health-related quality of life in obstructive sleep apnoea. European Respiratory Journal. 2002;19(3):499–503. doi: 10.1183/09031936.02.00216902. - DOI - PubMed
    1. Beiske K. K., Stavem K. Health status in subjects with suspected obstructive sleep apnea and comparison with a general population. Scientific Reports. 2018;8:p. 5579. doi: 10.1038/s41598-018-23904-3. - DOI - PMC - PubMed
    1. Kang J. M., Kang S.-G., Cho S.-J., et al. The quality of life of suspected obstructive sleep apnea patients is related to their subjective sleep quality rather than the apnea-hypopnea index. Sleep and Breathing. 2017;21(2):369–375. doi: 10.1007/s11325-016-1427-8. - DOI - PubMed
    1. American Academy of Sleep Medicine. International Classification of Sleep Disorders. Darien, IL, USA: American Academy of Sleep Medicine; 2014.
    1. Lusic Kalcina L., Valic M., Pecotic R., Pavlinac Dodig I., Dogas Z. Good and poor sleepers among OSA patients: sleep quality and overnight polysomnography findings. Neurological Sciences. 2017;38(7):1299–1306. doi: 10.1007/s10072-017-2978-6. - DOI - PubMed

LinkOut - more resources