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. 2020 Jun 9;7(7):001751.
doi: 10.12890/2020_001751. eCollection 2020.

Immune Thrombocytopenic Purpura in Patients with COVID-19

Sabine Revuz  1 , Nathalie Vernier  1 , Leilah Saadi  1 , Julien Campagne  1 , Sophie Poussing  1 , François Maurier  1
Affiliations

Immune Thrombocytopenic Purpura in Patients with COVID-19

Sabine Revuz et al. Eur J Case Rep Intern Med. .

Abstract

We described three COVID-19-infected patients with profound immune thrombocytopenia causing haemorrhagic mucocutaneous complications. We conclude that an immune mechanism was responsible as common causes were excluded. Since corticoids were considered harmful in the circumstances, the patients were successfully treated with intravenous immunoglobulins without later relapse.

Learning points: The severity of haemorrhagic syndrome is not correlated with the severity of COVID-19 infection.Thrombocytopenia in mild COVID-19 infection seems to have an autoimmune mechanism.Intravenous immunoglobulins (1 g/kg) should be the first line of treatment.

Keywords: COVID-19; SARS-CoV-2; intravenous immunoglobulins; thrombocytopenia.

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Conflict of interest statement

Conflicts of Interests: The Authors declare that there are no competing interests.

References

    1. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368:m1091. - PMC - PubMed
    1. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145–148. - PMC - PubMed
    1. Zulfiqar AA, Lorenzo-Villalba N, Hassler P, Andrès E. Immune thrombocytopenic purpura in a patient with Covid-19. N Engl J Med. 2020;382(18):e43. - PMC - PubMed
    1. Provan D, Arnold DM, Bussel JB, Chong BH, Cooper N, Gernsheimer T, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019;3:3780–3817. - PMC - PubMed
    1. Henry BM, Vikse J, Benoit S, Favaloro EJ, Lippi G. Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Clin Chim Acta. 2020;507:167–173. - PMC - PubMed

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