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Multicenter Study
. 2021 Jun;26(5):1447-1455.
doi: 10.1007/s40519-020-00959-8. Epub 2020 Jul 15.

Poor kidney graft survival in anorexia nervosa patients

Magalie Geneviève  1   2 , Albane Sartorius  3 , Magali Giral  4   5 , Bénédicte Janbon  6 , Pierre Merville  7   8 , Christophe Legendre  9   10 , Christian Combe  7   8 , Karine Moreau  7
Affiliations
Multicenter Study

Poor kidney graft survival in anorexia nervosa patients

Magalie Geneviève et al. Eat Weight Disord. 2021 Jun.

Abstract

Background: Anorexia nervosa is a condition associated with poor outcomes in a variety of circumstances such as recurrence of eating disorders, psychiatric disorders, and organ damage.

Objective: In the present study, we first sought to determine the 5-year kidney graft survival in patients with anorexia nervosa and then to evaluate the BMI course and medical complications.

Methods: In this multicenter, retrospective, case-control study, we analyzed the impact of anorexia nervosa on graft outcomes compared to transplant recipients with low or normal BMI.

Results: We enrolled 137 women in this study: 19 with anorexia nervosa, 59 with low BMI (BMI < 18.5 kg/m2), and 59 with normal BMI (18.5-24.9 kg/m2). Anorexia nervosa was significantly associated with lower graft survival compared to either of the other groups (hazard ratio 5.5 [95% CI 3.4-8.9], p = 0.005); there was no difference in graft survival between patients with low or normal BMI. Cardiovascular complications were more frequent in the anorexia nervosa group (37%) than in patients with low (6%) or normal BMI (7%) (p = 0.001).

Conclusion: We conclude that patients with anorexia nervosa should be considered a high-risk group.

Level of evidence: Level III, evidence obtained from well-designed cohort or case-control analytic studies.

Keywords: Anorexia nervosa; Body mass index; Graft survival; Kidney transplantation.

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