Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov;60(6):194-198.
doi: 10.1111/cga.12385. Epub 2020 Aug 7.

Clinical characteristics of congenital toxoplasmosis with poor outcome in Japan: A nationwide survey and literature review

Midori Hijikata  1 , Aya Okahashi  1 , Nobuhiko Nagano  1 , Ichiro Morioka  1
Affiliations
Review

Clinical characteristics of congenital toxoplasmosis with poor outcome in Japan: A nationwide survey and literature review

Midori Hijikata et al. Congenit Anom (Kyoto). 2020 Nov.

Abstract

The clinical characteristics of congenital toxoplasmosis cases with poor outcomes in Japan were analyzed. Ten cases were selected, identified from a nationwide survey by the Japan Society for Neonatal Health and Development and a literature review. Based on outcomes, two fatal cases showed generalized symptoms at birth; four cases with neurological sequelae showed the three main congenital toxoplasmosis manifestations (chorioretinitis, intracranial calcification, hydrocephalus); four cases with ophthalmological sequelae showed only one or two of the three main manifestations. Eight cases with poor outcomes were not prenatally diagnosed with congenital toxoplasma infection or suspected maternal toxoplasma infection. The outcome of congenital toxoplasmosis might differ depending on the symptomology.

Keywords: clinical symptoms; congenital toxoplasmosis; death; outcome; sequelae.

PubMed Disclaimer

References

REFERENCES

    1. Michaels MG, Sanchez P, Ling Lin P. Congenital toxoplasmosis. Avery's Diseases of the Newborns. Philadelphia: Elsevier; 2018:627-632.
    1. American Academy of Pediatrics. Toxoplasma gondii infection. Report of the Committee on Infectious Diseases 30th Edition. Elk Grove Village: American Academy of Pediatrics; 2015:787-796.
    1. Swisher CN, Boyer K, McLeod R. Congenital toxoplasmosis. The toxoplasmosis study group. Semin Pediatr Neurol. 1994;1:4-25.
    1. Nakashima H, Nakano M, Yano A, Aisai F. A case of severe congenital toxoplasmosis caused by raw horsemeat diet during pregnancy (in Japanese). Shonika Shinryo. 2010;73:1046-1049.
    1. Suzuki Y, Takemoto O, Arai H, et al. A case of congenital toxoplasmosis confirmed by detection of toxoplasma gondii in placenta (in Japanese). No To Hattatsu. 1998;30:411-416.

LinkOut - more resources