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Observational Study
. 2020 Jun;32(2):245-250.
doi: 10.5935/0103-507x.20200029. Epub 2020 Jun 24.

Time to clearance of abdominal septic focus and mortality in patients with sepsis

[Article in English, Portuguese]
Rafael Barberena Moraes  1 , Thiago Ferreira Serafini  1 , Josi Vidart  1 , Miriane Melo Silveira Moretti  1 , Jaqueline Sangiogo Haas  1 , Alan Pagnoncelli  1 , Marco Aurélio Abreu Azeredo  1 , Gilberto Friedman  1
Affiliations
Observational Study

Time to clearance of abdominal septic focus and mortality in patients with sepsis

[Article in English, Portuguese]
Rafael Barberena Moraes et al. Rev Bras Ter Intensiva. 2020 Jun.

Abstract
in English, Portuguese

Objective: To assess the relationship between time to focus clearance and hospital mortality in patients with sepsis and septic shock.

Methods: This was an observational, single-center study with a retrospective analysis of the time to clearance of abdominal septic focus. Patients were classified according to the time to focus clearance into an early (≤ 12 hours) or delayed (> 12 hours) group.

Results: A total of 135 patients were evaluated. There was no association between time to focus clearance and hospital mortality (≤ 12 hours versus > 12 hours): 52.3% versus 52.9%, with p = 0.137.

Conclusion: There was no difference in hospital mortality among patients with sepsis or septic shock who had an infectious focus evacuated before or after 12 hours after the diagnosis of sepsis.

Objetivo: Aferir a relação entre tempo para evacuação de foco e mortalidade hospitalar em portadores de sepse e choque séptico.

Métodos: Estudo observacional, unicêntrico, com análise retrospectiva do tempo para evacuação de foco séptico abdominal. Os pacientes foram classificados conforme o tempo para evacuação do foco em grupo precoce (≤ 12 horas) ou tardio (> 12 horas).

Resultados: Foram avaliados 135 pacientes. Não houve associação entre tempo para evacuação do foco e mortalidade hospitalar (≤ 12 horas versus > 12 horas): 52,3% versus 52,9%, com p = 0,137.

Conclusão: Não houve diferença na mortalidade hospitalar entre pacientes com sepse ou choque séptico que tiveram foco infeccioso evacuado antes ou após 12 horas do diagnóstico de sepse.

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Conflict of interest statement

Conflicts of interest: None.

Figures

Figure 1
Figure 1
Mortality (%) according to time to septic focus clearance (≤ 12 hours versus > 12 hours). 95%CI - 95% confidence interval.
See this image and copyright information in PMC

References

    1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303–1310. - PubMed
    1. Angus DC, Pereira CA, Silva E. Epidemiology of severe sepsis around the world. Endocr Metab Immune Disord Drug Targets. 2006;6(2):207–212. - PubMed
    1. Bozza FA, Salluh JI. An urban perspective on sepsis in developing countries. Lancet Infect Dis. 2010;10(5):290–291. - PubMed
    1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348(16):1546–1554. - PubMed
    1. Becker JU, Theodosis C, Jacob ST, Wira CR, Groce NE. Surviving sepsis in low-income and middle-income countries: new directions for care and research. Lancet Infect Dis. 2009;9(9):577–582. - PubMed

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