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Editorial
. 2020 Oct 15;202(8):1065-1067.
doi: 10.1164/rccm.202006-2164ED.

p16 INK4a and the Alveolar Niche Take Center Stage in Bronchopulmonary Dysplasia

Cho-Ming Chao  1 , Saverio Bellusci  1   2 , Jarod A Zepp  3
Affiliations
Editorial

p16 INK4a and the Alveolar Niche Take Center Stage in Bronchopulmonary Dysplasia

Cho-Ming Chao et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Modeling p16INK4A expression in the context of the developing alveolar niche. (Interaction 1) Zysman and colleagues show that under hyperoxic conditions fibroblasts express p16INK4A. Fibroblasts that are Pdgfra positive and express p16INK4A display an increased lipid profile. It has been shown that Pdgfra-positive fibroblasts support AT2 cell self-renewal via an exchange of secreted factors (interaction 2). Under normal conditions, in the developing lung, Pdgfra-positive fibroblasts also include a transient secondary crest myofibroblast. In certain pathological conditions, myofibroblasts contribute to impaired lung function. Future work could explore how acquisition of the p16INK4A signature results in differentiation of these fibroblast subsets and impact on the alveolar niche (interactions 3–5). AT2 = alveolar type 2; BPD = bronchopulmonary dysplasia.
See this image and copyright information in PMC

Comment on

  • Targeting p16INK4a Promotes Lipofibroblasts and Alveolar Regeneration after Early-Life Injury.
    Zysman M, Baptista BR, Essari LA, Taghizadeh S, Thibault de Ménonville C, Giffard C, Issa A, Franco-Montoya ML, Breau M, Souktani R, Aissat A, Caeymaex L, Lizé M, Van Nhieu JT, Jung C, Rottier R, Cruzeiro MD, Adnot S, Epaud R, Chabot F, Lanone S, Boczkowski J, Boyer L. Zysman M, et al. Am J Respir Crit Care Med. 2020 Oct 15;202(8):1088-1104. doi: 10.1164/rccm.201908-1573OC. Am J Respir Crit Care Med. 2020. PMID: 32628504

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