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Editorial
. 2020 Oct 1;202(7):917-919.
doi: 10.1164/rccm.202006-2149ED.

Endothelial Oxygen Sensing in Alveolar Maintenance

Emma Hodson  1   2 , Peter Ratcliffe  1   3
Affiliations
Editorial

Endothelial Oxygen Sensing in Alveolar Maintenance

Emma Hodson et al. Am J Respir Crit Care Med. .
No abstract available

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Comment on

  • Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema.
    Pasupneti S, Tian W, Tu AB, Dahms P, Granucci E, Gandjeva A, Xiang M, Butcher EC, Semenza GL, Tuder RM, Jiang X, Nicolls MR. Pasupneti S, et al. Am J Respir Crit Care Med. 2020 Oct 1;202(7):983-995. doi: 10.1164/rccm.202001-0078OC. Am J Respir Crit Care Med. 2020. PMID: 32515984 Free PMC article.

References

    1. Pasupneti S, Tian W, Tu AB, Dahms P, Granucci E, Gandjeva A, et al. Endothelial HIF-2α as a key endogenous mediator preventing emphysema. Am J Respir Crit Care Med. 2020;202:983–995. - PMC - PubMed
    1. Kaelin WG, Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008;30:393–402. - PubMed
    1. Koh MY, Powis G. Passing the baton: the HIF switch. Trends Biochem Sci. 2012;37:364–372. - PMC - PubMed
    1. Cowburn AS, Crosby A, Macías D, Branco C, Colaço RDDR, Southwood M, et al. HIF2α-arginase axis is essential for the development of pulmonary hypertension. Proc Natl Acad Sci USA. 2016;113:8801–8806. - PMC - PubMed
    1. Sekhon HS, Thurlbeck WM. Lung growth in hypobaric normoxia, normobaric hypoxia, and hypobaric hypoxia in growing rats. I. Biochemistry. J Appl Physiol (1985) 1995;78:124–131. - PubMed

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