IFN-Independent STING Signaling: Friend or Foe?
- PMID: 32668231
- DOI: 10.1016/j.immuni.2020.06.021
IFN-Independent STING Signaling: Friend or Foe?
Abstract
In this issue, Wu et al. demonstrate the importance of the neglected interferon (IFN)-independent STING signaling axis in mice. They find that although this axis is important for antiviral HSV-1 resistance, it has a pro-cancer role by promoting T cell death.
Copyright © 2020 Elsevier Inc. All rights reserved.
Comment on
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Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.Immunity. 2020 Jul 14;53(1):115-126.e5. doi: 10.1016/j.immuni.2020.06.009. Epub 2020 Jul 7. Immunity. 2020. PMID: 32640258 Free PMC article.
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