[HLA typing of nasopharyngeal carcinoma in Hunan province]

Abstract

114 normal individuals and 60 NPC patients in Hunan province were randomized for HLA typing in our laboratory in 1982 and 1986. All the NPC patients were confirmed by pathology. The HLA typing was performed before the treatment had been started. The results showed that the frequency of DRw8 in the NPC group was significantly higher than the normal group, but the frequencies of DR1 and Bw6 of the former were significantly lower than those of the latter in 1982. It was observed that Cw7 and DR4 were significantly higher in NPC group than that in the normal, but Bw6 and Cw1 were significantly lower in the former than the latter in 1986. It was found that DRw8 and Cw7 in the NPC group were still much higher than that in the normal, but DR1 in the former was much lower than that in the latter after analysing the data of 1982 and 1986. There is no information about the increase of HLA-DR or decrease of DR1 in NPC patients. It was found, however, DRw8 of NPC group was significantly higher than that of the normal, but DR1 in the former was significantly lower than that in the latter as observed in our laboratory.