Correction: Ordoñez, et al.; DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters? Cancers 2019, 11, 1424

Abstract

The authors would like to make a correction to their published paper [...].

Figure 1

Chromatin landscape for heterochromatin, poised and active enhancer regions. (A) The inactive DNA is tightly packed around histone proteins marked with H3K27me3 modification, in the form of heterochromatin. This structure prevents any interactions between transcription factors (TF) and the DNA sequence. (B) When the enhancer region is preactivated or poised, addition of H3K4me1 to the histone tails make the nucleosomes mobile, allowing for their displacement to form highly accessible DNA regions, which get frequently demethylated. (C) Upon activation of enhancer region, nucleosomes flanking this region acquire H3K27ac, losing the repressing H3K27me3 mark, which subsequently recruits the corresponding transcription factors.