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. 2014 Mar 18:4:65-75.
doi: 10.2147/DNND.S40349. eCollection 2014.

Neurogenic overactive bladder in spinal cord injury and multiple sclerosis: role of onabotulinumtoxinA

K D Ethans  1   2 , A R Casey  1   2 , R J Bard  1   3 , M P Namaka  1
Affiliations

Neurogenic overactive bladder in spinal cord injury and multiple sclerosis: role of onabotulinumtoxinA

K D Ethans et al. Degener Neurol Neuromuscul Dis. .

Abstract

People with neurogenic overactive bladder from either multiple sclerosis or spinal cord injury often suffer significant morbidity and decreased quality of life. Here we review the pathophysiology of neurogenic overactive bladder and the impact it can have on people with multiple sclerosis or spinal cord injury. We also address the various traditional treatment options and focus on the use of botulinum toxin A (specifically onabotulinumtoxinA) for this condition.

Keywords: multiple sclerosis; neurogenic detrusor overactivity; onabotulinumtoxinA; overactive bladder; spinal cord injury.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Mechanism of overactivity of the detrusor in SCI. Black font indicates normal anatomy and red font represents changes after a spinal cord lesion. Abbreviations: M3 receptors, muscarinic subtype 3 acetylcholine receptors; TRPV1, transient receptor potential cation channel subfamily V member 1 (C-fiber receptor); SCI, spinal cord injury; S2–S4, sacral level 2–4; PMC, pontine micturition center.
See this image and copyright information in PMC

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