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Review
. 2020 Jul 1;12(1):e2020039.
doi: 10.4084/MJHID.2020.039. eCollection 2020.

Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection

Donato Rigante  1   2
Affiliations
Review

Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection

Donato Rigante. Mediterr J Hematol Infect Dis. .

Abstract

Although the etiology of Kawasaki disease (KD) remains elusive, the available evidence indicates that the primum movens may be a dysregulated immune response to various microbial agents, leading to cytokine cascade and endothelial cell activation in patients with KD. Documented infections by different viruses in many individual cases have been largely reported and are discussed herein, but attempts to demonstrate their causative role in the distinctive KD scenario and KD epidemiological features have been disappointing. To date, no definite link has been irrefutably found between a single infection and KD.

Keywords: COVID-19; Child; Kawasaki disease; Personalized medicine; Viral infection.

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Conflict of interest statement

Competing interests: The authors declare no conflict of Interest.

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