Focusing On A Unique Innate Memory Cell Population Of Natural Killer Cells In The Fight Against COVID-19: Harnessing The Ubiquity Of Cytomegalovirus Exposure

Sarita Rani Jaiswal^{1

2}, Pankaj Malhotra³, Dipendra K Mitra⁴, Suparno Chakrabarti^{1

2}

Affiliations

¹ Cellular Therapy and Immunology, Manashi Chakrabarti Foundation.
² Department of Blood and Marrow Transplantation Dharamshila Narayana Super-speciality Hospital, New Delhi, India.
³ Clinical Hematology, Department of Internal Medicine, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
⁴ Department of Immunology, All India Institute of Medical Sciences, New Delhi, India.

Sarita Rani Jaiswal et al. Mediterr J Hematol Infect Dis. 2020.

. 2020 Jul 1;12(1):e2020047.

doi: 10.4084/MJHID.2020.047. eCollection 2020.

Sarita Rani Jaiswal^{1

2}, Pankaj Malhotra³, Dipendra K Mitra⁴, Suparno Chakrabarti^{1

2}

¹ Cellular Therapy and Immunology, Manashi Chakrabarti Foundation.
² Department of Blood and Marrow Transplantation Dharamshila Narayana Super-speciality Hospital, New Delhi, India.
³ Clinical Hematology, Department of Internal Medicine, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
⁴ Department of Immunology, All India Institute of Medical Sciences, New Delhi, India.

No abstract available

Keywords: COVID-19; Immunotherapy; Influenza; NK cells; NKG2A; NKG2C; SARS-CoV-2.

Conflict of interest statement

Competing interests: The authors declare no conflict of Interest.

1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed
1. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 doi: 10.1101/2020.02.06.20020974. - DOI - PMC - PubMed
1. Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H, et al. Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J Clin Invest. 2020 doi: 10.1101/2020.02.16.20023903. - DOI - PMC - PubMed
1. Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, Chen H, Wang D, Liu N, Liu D, et al. Characteristics of COVID-19 infection in Beijing. J Infect. 2020;80(4):401–406. doi: 10.1016/j.jinf.2020.02.018. - DOI - PMC - PubMed
1. Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents. 2020 doi: 10.1016/j.ijantimicag.2020.105954. 105954. - DOI - PMC - PubMed