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Case Reports
. 2020 Jun 15:33:100602.
doi: 10.1016/j.gore.2020.100602. eCollection 2020 Aug.

Treatment of invasive Paget's disease of the vulva in pregnancy: A case report

Kelly H Bruce  1 , Arthur-Quan M Tran  2
Affiliations
Case Reports

Treatment of invasive Paget's disease of the vulva in pregnancy: A case report

Kelly H Bruce et al. Gynecol Oncol Rep. .

Abstract

•Invasive adenocarcinoma of the vulva arising from extramammary Paget's disease is possible in women of child-bearing age.•Radical vulvectomy, sentinel lymph node biopsy, and inguinal lymphadenectomy are safe and feasible during pregnancy.•Chemotherapy may be used as adjuvant therapy for vulvar adenocarcinoma during pregnancy when radiation is contraindicated.•Primary cesarean delivery may be considered for pregnant women with recent vulvar surgery.•Trastuzumab may be considered for maintenance therapy of Her2/Neu positive vulvar cancer in postpartum women.

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Conflict of interest statement

The authors declared that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Punch biopsy of vulvar lesion showing invasive extramammary Paget’s disease, H&E stain at (a) 20× and (b) 200×. Tumor cells expressed pancytokeratin, CK7, and breast mix (BRST2 + mammaglobin). S100 and SOX10 were negative.
Fig. 2
Fig. 2
Left vulvar lesion prior to excision. Final pathology was consistent with invasive adenocarcinoma in association with extramammary Paget’s disease.
See this image and copyright information in PMC

References

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